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Neutrophil function, nitric oxide, and blood oxidative stress in Parkinson's disease.
Mov Disord. 1996 May; 11(3):261-7.MD

Abstract

We studied nitrogen radical nitric oxide (.NO) release and reactive oxygen species (ROS) production by isolated neutrophils after phorbol myristate acetate (PMA) stimulation in 12 newly diagnosed and nine treated Parkinson's disease (PD) patients and 10 age-matched healthy controls. Neutrophils of both groups of PD patients had an elevated PMA-activated release of .NO [61 and 57%, respectively, higher than that of controls (p < 0.05)]. In contrast, H2O2 release was only significantly increased by 56% in chronically treated patients. In agreement, the maximum rate of luminol-dependent chemiluminescence, which partly represents O2- H2O2- .NO interactions, was increased only in the treated group. When other blood markers of oxidative stress were compared, only erythrocyte catalase activity was decreased in both PD patient series by 33 and 39%, respectively (p < 0.05), whereas plasma antioxidant capacity and erythrocyte superoxide dismutase activity levels were decreased only in treated PD patients. This study suggests that neutrophils express a primary alteration of .NO release in PD patients, whereas H2O2 and oxidative-stress parameters are more probably related to the evolution of PD or to effects of treatment with L-dopa.

Authors+Show Affiliations

Section of Neurology, Hospital de Clínicas José de San Martín, School of Medicine, University of Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8723142

Citation

Gatto, E M., et al. "Neutrophil Function, Nitric Oxide, and Blood Oxidative Stress in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 11, no. 3, 1996, pp. 261-7.
Gatto EM, Carreras MC, Pargament GA, et al. Neutrophil function, nitric oxide, and blood oxidative stress in Parkinson's disease. Mov Disord. 1996;11(3):261-7.
Gatto, E. M., Carreras, M. C., Pargament, G. A., Riobo, N. A., Reides, C., Repetto, M., Fernandez Pardal, M. M., Llesuy, S., & Poderoso, J. J. (1996). Neutrophil function, nitric oxide, and blood oxidative stress in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 11(3), 261-7.
Gatto EM, et al. Neutrophil Function, Nitric Oxide, and Blood Oxidative Stress in Parkinson's Disease. Mov Disord. 1996;11(3):261-7. PubMed PMID: 8723142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neutrophil function, nitric oxide, and blood oxidative stress in Parkinson's disease. AU - Gatto,E M, AU - Carreras,M C, AU - Pargament,G A, AU - Riobo,N A, AU - Reides,C, AU - Repetto,M, AU - Fernandez Pardal,M M, AU - Llesuy,S, AU - Poderoso,J J, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 261 EP - 7 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 11 IS - 3 N2 - We studied nitrogen radical nitric oxide (.NO) release and reactive oxygen species (ROS) production by isolated neutrophils after phorbol myristate acetate (PMA) stimulation in 12 newly diagnosed and nine treated Parkinson's disease (PD) patients and 10 age-matched healthy controls. Neutrophils of both groups of PD patients had an elevated PMA-activated release of .NO [61 and 57%, respectively, higher than that of controls (p < 0.05)]. In contrast, H2O2 release was only significantly increased by 56% in chronically treated patients. In agreement, the maximum rate of luminol-dependent chemiluminescence, which partly represents O2- H2O2- .NO interactions, was increased only in the treated group. When other blood markers of oxidative stress were compared, only erythrocyte catalase activity was decreased in both PD patient series by 33 and 39%, respectively (p < 0.05), whereas plasma antioxidant capacity and erythrocyte superoxide dismutase activity levels were decreased only in treated PD patients. This study suggests that neutrophils express a primary alteration of .NO release in PD patients, whereas H2O2 and oxidative-stress parameters are more probably related to the evolution of PD or to effects of treatment with L-dopa. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/8723142/Neutrophil_function_nitric_oxide_and_blood_oxidative_stress_in_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.870110308 DB - PRIME DP - Unbound Medicine ER -