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CD4+ T cell inducible immunoregulatory cytokine response in rheumatoid arthritis.
J Rheumatol. 1996 May; 23(5):809-14.JR

Abstract

OBJECTIVE

Monocytes and CD4+/CD8+ T cells produce immunoregulatory cytokines that participate in the pathogenesis of various immune disorders. We investigated the secretion of Th1-Th2 cell response cytokine production of CD4+/CD8+ T cells from the synovial fluid (SF) and blood of patients with rheumatoid arthritis (RA).

METHODS

Blood and SF purified monocytes, CD4+ and CD8+ T cells were stimulated with bacterial lipopolysaccharides or anti-CD3 antibody, and secretion of various cytokines was determined by bioassay or ELISA:

RESULTS

Monocytes from SF and blood of patients with RA produced highly elevated levels of interleukin-1 alpha (IL-1 alpha), IL-6, tumor necrosis factor-alpha (TNF-alpha), and granulocyte macrophage colony stimulating factor (GMCSF), the leading mediators of inflammation. However, CD4+ T cells secreted deficient levels of IL-2 and interferon-gamma (IFN-gamma), but higher levels of IL-4 and IL-10, the typical immunoregulatory Th2 cell response cytokines. CD8+ T cells also produce elevated levels of IL-4 and IL-10 but almost normal levels of IFN-gamma in this disease.

CONCLUSION

The cytokine produced by monocytes (IL-alpha, IL-6, TNF-alpha, and GMCSF) and by CD4+ T cells Th2 cell responses (IL-4 and IL-10) may exert immunopathologic and immunoregulatory effects in SF and thus mediate some of the clinical manifestations of RA.

Authors+Show Affiliations

Department of Medicine, College of Medicine, King Saud University, Abha, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8724289

Citation

al-Janadi, N, et al. "CD4+ T Cell Inducible Immunoregulatory Cytokine Response in Rheumatoid Arthritis." The Journal of Rheumatology, vol. 23, no. 5, 1996, pp. 809-14.
al-Janadi N, al-Dalaan A, al-Balla S, et al. CD4+ T cell inducible immunoregulatory cytokine response in rheumatoid arthritis. J Rheumatol. 1996;23(5):809-14.
al-Janadi, N., al-Dalaan, A., al-Balla, S., & Raziuddin, S. (1996). CD4+ T cell inducible immunoregulatory cytokine response in rheumatoid arthritis. The Journal of Rheumatology, 23(5), 809-14.
al-Janadi N, et al. CD4+ T Cell Inducible Immunoregulatory Cytokine Response in Rheumatoid Arthritis. J Rheumatol. 1996;23(5):809-14. PubMed PMID: 8724289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD4+ T cell inducible immunoregulatory cytokine response in rheumatoid arthritis. AU - al-Janadi,N, AU - al-Dalaan,A, AU - al-Balla,S, AU - Raziuddin,S, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 809 EP - 14 JF - The Journal of rheumatology JO - J Rheumatol VL - 23 IS - 5 N2 - OBJECTIVE: Monocytes and CD4+/CD8+ T cells produce immunoregulatory cytokines that participate in the pathogenesis of various immune disorders. We investigated the secretion of Th1-Th2 cell response cytokine production of CD4+/CD8+ T cells from the synovial fluid (SF) and blood of patients with rheumatoid arthritis (RA). METHODS: Blood and SF purified monocytes, CD4+ and CD8+ T cells were stimulated with bacterial lipopolysaccharides or anti-CD3 antibody, and secretion of various cytokines was determined by bioassay or ELISA: RESULTS: Monocytes from SF and blood of patients with RA produced highly elevated levels of interleukin-1 alpha (IL-1 alpha), IL-6, tumor necrosis factor-alpha (TNF-alpha), and granulocyte macrophage colony stimulating factor (GMCSF), the leading mediators of inflammation. However, CD4+ T cells secreted deficient levels of IL-2 and interferon-gamma (IFN-gamma), but higher levels of IL-4 and IL-10, the typical immunoregulatory Th2 cell response cytokines. CD8+ T cells also produce elevated levels of IL-4 and IL-10 but almost normal levels of IFN-gamma in this disease. CONCLUSION: The cytokine produced by monocytes (IL-alpha, IL-6, TNF-alpha, and GMCSF) and by CD4+ T cells Th2 cell responses (IL-4 and IL-10) may exert immunopathologic and immunoregulatory effects in SF and thus mediate some of the clinical manifestations of RA. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/8724289/CD4+_T_cell_inducible_immunoregulatory_cytokine_response_in_rheumatoid_arthritis_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -