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Calcitonin gene-related peptide reverses the hypertension and significantly decreases the fetal mortality in pre-eclampsia rats induced by N(G)-nitro-L-arginine methyl ester.
Hum Reprod. 1996 Apr; 11(4):895-9.HR

Abstract

We recently established that the chronic inhibition of nitric oxide production with N(G)-nitro-L-arginine methyl ester (L-NAME) increases blood pressure and fetal mortality in pregnant rats. Using this animal model, we have investigated whether calcitonin gene-related peptide (CGRP) can reverse the pre-eclampsia-like conditions produced by L-NAME. CGRP and L-NAME were chronically infused s.c. into pregnant rats separately or together starting on day 17 of gestation; a control group was given saline infusions. Systolic blood pressure was measured on gestational days 17, 18, 19 and 22 and post-partum days 1 and 2. The weight and mortality of the pups were recorded immediately after spontaneous delivery. Animals treated with L-NAME exhibited significant elevations of blood pressure on days 18, 19 and 22 of gestation and during post-partum, increased pup mortality (18.4 versus 0.0%) and decreased pup weights (5.14 +/- 0.07 versus 6.20 +/- 0.06 g). The co-administration of L-NAME and CGRP prevented the gestational (not the post-partum) L-NAME hypertension and decreased pup mortality to 6.4% but did not reverse the decreased fetal weight (5.31 +/- 0.06 g). Our data indicate the CGRP (i) participates in regulation of the vascular adaptations that occur during normal pregnancy, (ii) has beneficial effects on the hypertension and increased mortality of experimental preeclampsia, and (iii) may exert differential effects on the systemic (i.e. maternal) and fetal components of utero-placental circulation. These findings may have important clinical implications.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston 77555-1062, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8724798

Citation

Yallampalli, C, et al. "Calcitonin Gene-related Peptide Reverses the Hypertension and Significantly Decreases the Fetal Mortality in Pre-eclampsia Rats Induced By N(G)-nitro-L-arginine Methyl Ester." Human Reproduction (Oxford, England), vol. 11, no. 4, 1996, pp. 895-9.
Yallampalli C, Dong YL, Wimalawansa SJ. Calcitonin gene-related peptide reverses the hypertension and significantly decreases the fetal mortality in pre-eclampsia rats induced by N(G)-nitro-L-arginine methyl ester. Hum Reprod. 1996;11(4):895-9.
Yallampalli, C., Dong, Y. L., & Wimalawansa, S. J. (1996). Calcitonin gene-related peptide reverses the hypertension and significantly decreases the fetal mortality in pre-eclampsia rats induced by N(G)-nitro-L-arginine methyl ester. Human Reproduction (Oxford, England), 11(4), 895-9.
Yallampalli C, Dong YL, Wimalawansa SJ. Calcitonin Gene-related Peptide Reverses the Hypertension and Significantly Decreases the Fetal Mortality in Pre-eclampsia Rats Induced By N(G)-nitro-L-arginine Methyl Ester. Hum Reprod. 1996;11(4):895-9. PubMed PMID: 8724798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcitonin gene-related peptide reverses the hypertension and significantly decreases the fetal mortality in pre-eclampsia rats induced by N(G)-nitro-L-arginine methyl ester. AU - Yallampalli,C, AU - Dong,Y L, AU - Wimalawansa,S J, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 895 EP - 9 JF - Human reproduction (Oxford, England) JO - Hum Reprod VL - 11 IS - 4 N2 - We recently established that the chronic inhibition of nitric oxide production with N(G)-nitro-L-arginine methyl ester (L-NAME) increases blood pressure and fetal mortality in pregnant rats. Using this animal model, we have investigated whether calcitonin gene-related peptide (CGRP) can reverse the pre-eclampsia-like conditions produced by L-NAME. CGRP and L-NAME were chronically infused s.c. into pregnant rats separately or together starting on day 17 of gestation; a control group was given saline infusions. Systolic blood pressure was measured on gestational days 17, 18, 19 and 22 and post-partum days 1 and 2. The weight and mortality of the pups were recorded immediately after spontaneous delivery. Animals treated with L-NAME exhibited significant elevations of blood pressure on days 18, 19 and 22 of gestation and during post-partum, increased pup mortality (18.4 versus 0.0%) and decreased pup weights (5.14 +/- 0.07 versus 6.20 +/- 0.06 g). The co-administration of L-NAME and CGRP prevented the gestational (not the post-partum) L-NAME hypertension and decreased pup mortality to 6.4% but did not reverse the decreased fetal weight (5.31 +/- 0.06 g). Our data indicate the CGRP (i) participates in regulation of the vascular adaptations that occur during normal pregnancy, (ii) has beneficial effects on the hypertension and increased mortality of experimental preeclampsia, and (iii) may exert differential effects on the systemic (i.e. maternal) and fetal components of utero-placental circulation. These findings may have important clinical implications. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/8724798/Calcitonin_gene_related_peptide_reverses_the_hypertension_and_significantly_decreases_the_fetal_mortality_in_pre_eclampsia_rats_induced_by_N_G__nitro_L_arginine_methyl_ester_ L2 - https://antibodies.cancer.gov/detail/CPTC-S100A12-1 DB - PRIME DP - Unbound Medicine ER -