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Allelic association but only weak evidence for linkage to the apolipoprotein E locus in late-onset Swedish Alzheimer families.
Am J Med Genet. 1996 May 31; 67(3):306-11.AJ

Abstract

An association between the epsilon 4 allele of the apolipoprotein E gene (APOE) and late-onset Alzheimer's disease (AD) was recently demonstrated. In order to confirm the association and to gauge the ability of standard genetic linkage methods to identify susceptibility genes, we investigated 15 Swedish late-onset Ad families. We found an association of familial AD to the APOE epsilon 4 allele (P = 0.01) but no indication of linkage to the APOE region using 2-point linkage analysis, and only weak evidence using the affected pedigree-member (APM) method. Our results confirm an APOE epsilon 4 association with late-onset familial AD and indicate that susceptibility genes can easily be missed when using standard lod score and APM genetic linkage analysis.

Authors+Show Affiliations

Karolinska Institute, Department of Clinical Neuroscience, Huddinge, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8725748

Citation

Liu, L, et al. "Allelic Association but Only Weak Evidence for Linkage to the Apolipoprotein E Locus in Late-onset Swedish Alzheimer Families." American Journal of Medical Genetics, vol. 67, no. 3, 1996, pp. 306-11.
Liu L, Forsell C, Lilius L, et al. Allelic association but only weak evidence for linkage to the apolipoprotein E locus in late-onset Swedish Alzheimer families. Am J Med Genet. 1996;67(3):306-11.
Liu, L., Forsell, C., Lilius, L., Axelman, K., Corder, E. H., & Lannfelt, L. (1996). Allelic association but only weak evidence for linkage to the apolipoprotein E locus in late-onset Swedish Alzheimer families. American Journal of Medical Genetics, 67(3), 306-11.
Liu L, et al. Allelic Association but Only Weak Evidence for Linkage to the Apolipoprotein E Locus in Late-onset Swedish Alzheimer Families. Am J Med Genet. 1996 May 31;67(3):306-11. PubMed PMID: 8725748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allelic association but only weak evidence for linkage to the apolipoprotein E locus in late-onset Swedish Alzheimer families. AU - Liu,L, AU - Forsell,C, AU - Lilius,L, AU - Axelman,K, AU - Corder,E H, AU - Lannfelt,L, PY - 1996/5/31/pubmed PY - 2000/6/20/medline PY - 1996/5/31/entrez SP - 306 EP - 11 JF - American journal of medical genetics JO - Am. J. Med. Genet. VL - 67 IS - 3 N2 - An association between the epsilon 4 allele of the apolipoprotein E gene (APOE) and late-onset Alzheimer's disease (AD) was recently demonstrated. In order to confirm the association and to gauge the ability of standard genetic linkage methods to identify susceptibility genes, we investigated 15 Swedish late-onset Ad families. We found an association of familial AD to the APOE epsilon 4 allele (P = 0.01) but no indication of linkage to the APOE region using 2-point linkage analysis, and only weak evidence using the affected pedigree-member (APM) method. Our results confirm an APOE epsilon 4 association with late-onset familial AD and indicate that susceptibility genes can easily be missed when using standard lod score and APM genetic linkage analysis. SN - 0148-7299 UR - https://www.unboundmedicine.com/medline/citation/8725748/Allelic_association_but_only_weak_evidence_for_linkage_to_the_apolipoprotein_E_locus_in_late_onset_Swedish_Alzheimer_families_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0148-7299&date=1996&volume=67&issue=3&spage=306 DB - PRIME DP - Unbound Medicine ER -