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Uterine myomas and smoking. Results from an Italian study.
J Reprod Med 1996; 41(5):316-20JR

Abstract

OBJECTIVE

To evaluate the relationship between smoking and uterine myomas requiring surgery.

STUDY DESIGN

We conducted a case-control study in Milan between 1986 and 1992. Cases were 476 patients under 55 years of age with histologically confirmed myomas. Controls were 1,283 women admitted to the hospital for a spectrum of acute, other-than-gynecologic, hormonal or neoplastic conditions (30% trauma, 25% nontraumatic orthopedic conditions, 25% surgical, 20% other miscellaneous).

RESULTS

Cases were less frequently current smokers (22%) than controls (32%). In comparison with never smokers, the multivariate relative risk (RR) for myomas was 0.5 (95% confidence interval [CI], 0.4-0.7) in smokers. Ex-smokers were 10% of cases versus 7% of controls (RR 1.2, 95% CI 0.9-1.8). No clear trend in risk was observed with the number of cigarettes smoked per day or duration of smoking and risk of fibroids. The estimated RRs were largely consistent when separate analyses were performed in strata of age and other selected covariates, including indices of body weight.

CONCLUSION

Current smoking seems to reduce the risk of myomas.

Authors+Show Affiliations

Istituto di Ricerche, Farmacologiche, Mario Negri, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8725755

Citation

Parazzini, F, et al. "Uterine Myomas and Smoking. Results From an Italian Study." The Journal of Reproductive Medicine, vol. 41, no. 5, 1996, pp. 316-20.
Parazzini F, Negri E, La Vecchia C, et al. Uterine myomas and smoking. Results from an Italian study. J Reprod Med. 1996;41(5):316-20.
Parazzini, F., Negri, E., La Vecchia, C., Rabaiotti, M., Luchini, L., Villa, A., & Fedele, L. (1996). Uterine myomas and smoking. Results from an Italian study. The Journal of Reproductive Medicine, 41(5), pp. 316-20.
Parazzini F, et al. Uterine Myomas and Smoking. Results From an Italian Study. J Reprod Med. 1996;41(5):316-20. PubMed PMID: 8725755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uterine myomas and smoking. Results from an Italian study. AU - Parazzini,F, AU - Negri,E, AU - La Vecchia,C, AU - Rabaiotti,M, AU - Luchini,L, AU - Villa,A, AU - Fedele,L, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 316 EP - 20 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 41 IS - 5 N2 - OBJECTIVE: To evaluate the relationship between smoking and uterine myomas requiring surgery. STUDY DESIGN: We conducted a case-control study in Milan between 1986 and 1992. Cases were 476 patients under 55 years of age with histologically confirmed myomas. Controls were 1,283 women admitted to the hospital for a spectrum of acute, other-than-gynecologic, hormonal or neoplastic conditions (30% trauma, 25% nontraumatic orthopedic conditions, 25% surgical, 20% other miscellaneous). RESULTS: Cases were less frequently current smokers (22%) than controls (32%). In comparison with never smokers, the multivariate relative risk (RR) for myomas was 0.5 (95% confidence interval [CI], 0.4-0.7) in smokers. Ex-smokers were 10% of cases versus 7% of controls (RR 1.2, 95% CI 0.9-1.8). No clear trend in risk was observed with the number of cigarettes smoked per day or duration of smoking and risk of fibroids. The estimated RRs were largely consistent when separate analyses were performed in strata of age and other selected covariates, including indices of body weight. CONCLUSION: Current smoking seems to reduce the risk of myomas. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/8725755/Uterine_myomas_and_smoking__Results_from_an_Italian_study_ L2 - https://medlineplus.gov/uterinefibroids.html DB - PRIME DP - Unbound Medicine ER -