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Cutis laxa acquisita associated with multiple myeloma: a case report and review of the literature.
Cutis. 1996 Apr; 57(4):267-70.C

Abstract

Cutis laxa acquisita is a rare disorder that affects collagen and elastin metabolism. The cause is unknown. Characteristic features include sagging and laxity of the skin, as well as involvement of the lungs, heart, gastrointestinal system, and urogenital tract. Three cases of cutis laxa acquisita have been reported in association with multiple myeloma. Due to the rarity of these disorders, a linkage has been postulated. The clinical and histologic data from the fourth case of cutis laxa acquisita associated with multiple myeloma were compared to the three other cases previously reported in the literature. The relationship between acquired cutis laxa and multiple myeloma is unclear, with only one case revealing possible immune-mediated elastin destruction via IgG immunoglobulin bound to dermal elastin fibers on immunofluoresence examination. No pattern in the clinical courses of the disorder can be seen on review of the four cases with coincident disease. We hypothesize that cutis laxa acquisita represents a paraneoplastic process of multiple myeloma, given the rarity of these diseases. Further investigation is necessary to determine the underlying linkage between these disorders. We suggest that serum and urine protein electrophoresis results be obtained in patients presenting with cutis laxa acquisita to screen for multiple myeloma given this association.

Authors+Show Affiliations

Hematology/Oncology Service, Womack Army Medical Center, Fort Bragg, North Carolina, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

8727781

Citation

McCarty, M J., et al. "Cutis Laxa Acquisita Associated With Multiple Myeloma: a Case Report and Review of the Literature." Cutis, vol. 57, no. 4, 1996, pp. 267-70.
McCarty MJ, Davidson JM, Cardone JS, et al. Cutis laxa acquisita associated with multiple myeloma: a case report and review of the literature. Cutis. 1996;57(4):267-70.
McCarty, M. J., Davidson, J. M., Cardone, J. S., & Anderson, L. L. (1996). Cutis laxa acquisita associated with multiple myeloma: a case report and review of the literature. Cutis, 57(4), 267-70.
McCarty MJ, et al. Cutis Laxa Acquisita Associated With Multiple Myeloma: a Case Report and Review of the Literature. Cutis. 1996;57(4):267-70. PubMed PMID: 8727781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutis laxa acquisita associated with multiple myeloma: a case report and review of the literature. AU - McCarty,M J, AU - Davidson,J M, AU - Cardone,J S, AU - Anderson,L L, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 267 EP - 70 JF - Cutis JO - Cutis VL - 57 IS - 4 N2 - Cutis laxa acquisita is a rare disorder that affects collagen and elastin metabolism. The cause is unknown. Characteristic features include sagging and laxity of the skin, as well as involvement of the lungs, heart, gastrointestinal system, and urogenital tract. Three cases of cutis laxa acquisita have been reported in association with multiple myeloma. Due to the rarity of these disorders, a linkage has been postulated. The clinical and histologic data from the fourth case of cutis laxa acquisita associated with multiple myeloma were compared to the three other cases previously reported in the literature. The relationship between acquired cutis laxa and multiple myeloma is unclear, with only one case revealing possible immune-mediated elastin destruction via IgG immunoglobulin bound to dermal elastin fibers on immunofluoresence examination. No pattern in the clinical courses of the disorder can be seen on review of the four cases with coincident disease. We hypothesize that cutis laxa acquisita represents a paraneoplastic process of multiple myeloma, given the rarity of these diseases. Further investigation is necessary to determine the underlying linkage between these disorders. We suggest that serum and urine protein electrophoresis results be obtained in patients presenting with cutis laxa acquisita to screen for multiple myeloma given this association. SN - 0011-4162 UR - https://www.unboundmedicine.com/medline/citation/8727781/Cutis_laxa_acquisita_associated_with_multiple_myeloma:_a_case_report_and_review_of_the_literature_ L2 - http://www.diseaseinfosearch.org/result/4962 DB - PRIME DP - Unbound Medicine ER -