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Abnormal colonic transit time in untreated celiac sprue.
Acta Gastroenterol Latinoam 1995; 25(5):277-84AG

Abstract

Motility disorders of the digestive tract have long been implicated in the pathophysiology of diarrhea in patients with celiac sprue. However, the contribution of the colon to the intestinal transit of celiac sprue has not been reported. Our aim was to determine whether sprue alters gut transit and whether differences in the clinical status of the disease influences colonic transit. We prospectively studied 25 patients with untreated celiac sprue, 15 treated patients and 15 healthy controls. Oro-cecal transit time, measured by the lactulose breath H2 test, was significantly delayed in untreated patients compared with treated patients and controls (p < 0.001 and p < 0.01 respectively). The delayed transit through the stomach and small bowel was not related to the presence of the steatorrhea. Transit of radiopaque makers, a measure of total colonic transit, was significantly faster in untreated patients (p < 0.05). The major finding was that this abnormal colonic behavior was principally due to a subpopulation of untreated patients with very fast transit times (< 18 hours). A weakly significant inverse correlation between transit and fecal weight (r: -0.55, p < 0.01), and between transit and steatorrhea (r: -0.38, p < 0.05), was observed. We confirm previous descriptions of delayed oro-cecal transit time in untreated patients, and also provide the first evidence that disordered colonic transit contributes to the pathophysiology of the diarrhea in sprue.

Authors+Show Affiliations

Clinical Service, Hospital de Gastroenterología C, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8733253

Citation

Bai, J C., et al. "Abnormal Colonic Transit Time in Untreated Celiac Sprue." Acta Gastroenterologica Latinoamericana, vol. 25, no. 5, 1995, pp. 277-84.
Bai JC, Mauriño E, Martínez C, et al. Abnormal colonic transit time in untreated celiac sprue. Acta Gastroenterol Latinoam. 1995;25(5):277-84.
Bai, J. C., Mauriño, E., Martínez, C., Vázquez, H., Niveloni, S., Soifer, G., ... Boerr, L. A. (1995). Abnormal colonic transit time in untreated celiac sprue. Acta Gastroenterologica Latinoamericana, 25(5), pp. 277-84.
Bai JC, et al. Abnormal Colonic Transit Time in Untreated Celiac Sprue. Acta Gastroenterol Latinoam. 1995;25(5):277-84. PubMed PMID: 8733253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal colonic transit time in untreated celiac sprue. AU - Bai,J C, AU - Mauriño,E, AU - Martínez,C, AU - Vázquez,H, AU - Niveloni,S, AU - Soifer,G, AU - Flores,D, AU - Boerr,L A, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 277 EP - 84 JF - Acta gastroenterologica Latinoamericana JO - Acta Gastroenterol. Latinoam. VL - 25 IS - 5 N2 - Motility disorders of the digestive tract have long been implicated in the pathophysiology of diarrhea in patients with celiac sprue. However, the contribution of the colon to the intestinal transit of celiac sprue has not been reported. Our aim was to determine whether sprue alters gut transit and whether differences in the clinical status of the disease influences colonic transit. We prospectively studied 25 patients with untreated celiac sprue, 15 treated patients and 15 healthy controls. Oro-cecal transit time, measured by the lactulose breath H2 test, was significantly delayed in untreated patients compared with treated patients and controls (p < 0.001 and p < 0.01 respectively). The delayed transit through the stomach and small bowel was not related to the presence of the steatorrhea. Transit of radiopaque makers, a measure of total colonic transit, was significantly faster in untreated patients (p < 0.05). The major finding was that this abnormal colonic behavior was principally due to a subpopulation of untreated patients with very fast transit times (< 18 hours). A weakly significant inverse correlation between transit and fecal weight (r: -0.55, p < 0.01), and between transit and steatorrhea (r: -0.38, p < 0.05), was observed. We confirm previous descriptions of delayed oro-cecal transit time in untreated patients, and also provide the first evidence that disordered colonic transit contributes to the pathophysiology of the diarrhea in sprue. SN - 0300-9033 UR - https://www.unboundmedicine.com/medline/citation/8733253/Abnormal_colonic_transit_time_in_untreated_celiac_sprue_ L2 - http://www.diseaseinfosearch.org/result/1188 DB - PRIME DP - Unbound Medicine ER -