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Oxidative stress in Parkinson's disease and other neurodegenerative disorders.
Pathol Biol (Paris). 1996 Jan; 44(1):57-64.PB

Abstract

The cause of cell death in neurodegenerative diseases remains unknown but the formation of free radicals and the occurrence of oxidative stress may be a common component of many, if not all, such disorders. For example, in substantia nigra in Parkinson's diseases key alterations occur, in iron handling, mitochondrial function and antioxidant defences, particularly reduced glutathione. These indices of oxidative stress are accompanied by evidence of free radical mediated damage in the form of increased lipid peroxidation and oxidation of DNA bases. The alterations in oxidative stress occurring in Parkinson's disease appear not be related to the administration of L-DOPA. Some alterations of oxidative stress are found in other basal ganglia in degenerative disorders (multiple system atrophy, progressive supranuclear palsy, Huntington's disease) but these have not been investigated to the same extent. Similarly, examination of biochemical changes occurring in Alzheimer's disease, motor neurone disease and diabetic neuropathy also suggest the involvement of free radical mediated mechanisms as a component of neurodegeneration. It is probable that irrespective of the primary cause of individual neurodegenerative disorder, the onset of oxidative stress is a common mechanism by which neuronal death occurs and which contributes to disease progression. Clearly, therapeutic strategies aimed at limiting free radical production and oxidative stress and/or damage may slow the advance of neurodegenerative disease.

Authors+Show Affiliations

Biomedical Sciences Division, King's College London, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

8734302

Citation

Jenner, P. "Oxidative Stress in Parkinson's Disease and Other Neurodegenerative Disorders." Pathologie-biologie, vol. 44, no. 1, 1996, pp. 57-64.
Jenner P. Oxidative stress in Parkinson's disease and other neurodegenerative disorders. Pathol Biol. 1996;44(1):57-64.
Jenner, P. (1996). Oxidative stress in Parkinson's disease and other neurodegenerative disorders. Pathologie-biologie, 44(1), 57-64.
Jenner P. Oxidative Stress in Parkinson's Disease and Other Neurodegenerative Disorders. Pathol Biol. 1996;44(1):57-64. PubMed PMID: 8734302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress in Parkinson's disease and other neurodegenerative disorders. A1 - Jenner,P, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 57 EP - 64 JF - Pathologie-biologie JO - Pathol. Biol. VL - 44 IS - 1 N2 - The cause of cell death in neurodegenerative diseases remains unknown but the formation of free radicals and the occurrence of oxidative stress may be a common component of many, if not all, such disorders. For example, in substantia nigra in Parkinson's diseases key alterations occur, in iron handling, mitochondrial function and antioxidant defences, particularly reduced glutathione. These indices of oxidative stress are accompanied by evidence of free radical mediated damage in the form of increased lipid peroxidation and oxidation of DNA bases. The alterations in oxidative stress occurring in Parkinson's disease appear not be related to the administration of L-DOPA. Some alterations of oxidative stress are found in other basal ganglia in degenerative disorders (multiple system atrophy, progressive supranuclear palsy, Huntington's disease) but these have not been investigated to the same extent. Similarly, examination of biochemical changes occurring in Alzheimer's disease, motor neurone disease and diabetic neuropathy also suggest the involvement of free radical mediated mechanisms as a component of neurodegeneration. It is probable that irrespective of the primary cause of individual neurodegenerative disorder, the onset of oxidative stress is a common mechanism by which neuronal death occurs and which contributes to disease progression. Clearly, therapeutic strategies aimed at limiting free radical production and oxidative stress and/or damage may slow the advance of neurodegenerative disease. SN - 0369-8114 UR - https://www.unboundmedicine.com/medline/citation/8734302/Oxidative_stress_in_Parkinson's_disease_and_other_neurodegenerative_disorders_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -