Tags

Type your tag names separated by a space and hit enter

Coeliac disease: frequent occurrence after clinical onset of insulin-dependent diabetes mellitus. Childhood Diabetes in Finland Study Group.
Diabet Med 1996; 13(5):464-70DM

Abstract

Coeliac disease was searched for in a series of 776 children with newly diagnosed IDDM. During the follow-up of 2 to 3 years from diagnosis, reticulin and gliadin antibodies were measured, and a jejunal biopsy was performed in those cases with high levels of antibodies; 19 children were identified with coeliac disease, giving the prevalence of 2.4%. In only one case had coeliac disease been diagnosed before IDDM. Nine patients with proven coeliac disease were negative for antibodies when IDDM was diagnosed, but became positive within 24 months. All patients found to have coeliac disease were positive for IgA reticulin antibodies, but only 12 of 18 (67%) showed a high level of IgA gliadin antibodies. Of the 18 patients genotyped for HLA DR locus, 14 (78%) were positive for DR3 and 10 (56%) were positive for DR4. DQB1*0201 allele was present in 17 of 18 patients (94%). Coeliac disease in children with IDDM tends to develop soon after diabetes is diagnosed. Routine screening for coeliac disease is recommended repeatedly during the first years after the diagnosis of IDDM.

Authors+Show Affiliations

Children's Hospital, I Department of Pediatrics, University of Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8737029

Citation

Saukkonen, T, et al. "Coeliac Disease: Frequent Occurrence After Clinical Onset of Insulin-dependent Diabetes Mellitus. Childhood Diabetes in Finland Study Group." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 13, no. 5, 1996, pp. 464-70.
Saukkonen T, Savilahti E, Reijonen H, et al. Coeliac disease: frequent occurrence after clinical onset of insulin-dependent diabetes mellitus. Childhood Diabetes in Finland Study Group. Diabet Med. 1996;13(5):464-70.
Saukkonen, T., Savilahti, E., Reijonen, H., Ilonen, J., Tuomilehto-Wolf, E., & Akerblom, H. K. (1996). Coeliac disease: frequent occurrence after clinical onset of insulin-dependent diabetes mellitus. Childhood Diabetes in Finland Study Group. Diabetic Medicine : a Journal of the British Diabetic Association, 13(5), pp. 464-70.
Saukkonen T, et al. Coeliac Disease: Frequent Occurrence After Clinical Onset of Insulin-dependent Diabetes Mellitus. Childhood Diabetes in Finland Study Group. Diabet Med. 1996;13(5):464-70. PubMed PMID: 8737029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coeliac disease: frequent occurrence after clinical onset of insulin-dependent diabetes mellitus. Childhood Diabetes in Finland Study Group. AU - Saukkonen,T, AU - Savilahti,E, AU - Reijonen,H, AU - Ilonen,J, AU - Tuomilehto-Wolf,E, AU - Akerblom,H K, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 464 EP - 70 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 13 IS - 5 N2 - Coeliac disease was searched for in a series of 776 children with newly diagnosed IDDM. During the follow-up of 2 to 3 years from diagnosis, reticulin and gliadin antibodies were measured, and a jejunal biopsy was performed in those cases with high levels of antibodies; 19 children were identified with coeliac disease, giving the prevalence of 2.4%. In only one case had coeliac disease been diagnosed before IDDM. Nine patients with proven coeliac disease were negative for antibodies when IDDM was diagnosed, but became positive within 24 months. All patients found to have coeliac disease were positive for IgA reticulin antibodies, but only 12 of 18 (67%) showed a high level of IgA gliadin antibodies. Of the 18 patients genotyped for HLA DR locus, 14 (78%) were positive for DR3 and 10 (56%) were positive for DR4. DQB1*0201 allele was present in 17 of 18 patients (94%). Coeliac disease in children with IDDM tends to develop soon after diabetes is diagnosed. Routine screening for coeliac disease is recommended repeatedly during the first years after the diagnosis of IDDM. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/8737029/Coeliac_disease:_frequent_occurrence_after_clinical_onset_of_insulin_dependent_diabetes_mellitus__Childhood_Diabetes_in_Finland_Study_Group_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -