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Effects of oral contraceptives on plasma neutral amino acids and cholesterol during a menstrual cycle.
Eur J Clin Pharmacol. 1996; 50(3):179-84.EJ

Abstract

OBJECTIVE

Concentrations of plasma neutral amino acids, i.e. threonine, serine, asparagine, glycine, alanine, citrulline, alpha-aminobutyric acid, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, and tryptophan, and serum cholesterol, were determined at the follicular (Day 4), mid-cycle (Day 16) and luteal (Day 25) phases of the menstrual cycle in 15 users of the new generation of combined oral contraceptives (OC), 11 on multiphase combined OC, and 17 controls.

RESULTS

The controls showed a decrease in the sum of amino acids to 95% at mid-cycle and 90% in the luteal phase relative to the follicular phase, and a significant decrease in the tyrosine level at the luteal relative to the follicular phase. Since there was no significant difference between the two OC subgroups in the levels of the specified variables at either of the phases, the two groups were considered together. The sum of amino acids in the OC group decreased to 89% at mid-cycle and 91% at the luteal phase relative to the follicular phase, indicating less metabolic effect than reported for older OC formulations. Compared to the controls, the OC group showed significant increased threonine level at the luteal phase, decreased glycine levels at mid-cycle and the luteal phases, decreased citrulline level at mid-cycle, and markedly decreased tyrosine levels at the mid-cycle and luteal phases. Neither total nor high density lipoprotein (HDL) cholesterol differed significantly between the control and OC groups.

CONCLUSION

The results suggest that the metabolic effects of the new generation combined OC on neutral amino acids and cholesterol are only modest to slight, except for the effect on tyrosine, the brain noradrenaline precursor, which may cause disturbances of various noradrenaline-mediated central functions in susceptible subjects.

Authors+Show Affiliations

Department of Clinical Pharmacology, St. Hans Psychiatric Hospital, Roskilde, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8737756

Citation

Moller, S E., et al. "Effects of Oral Contraceptives On Plasma Neutral Amino Acids and Cholesterol During a Menstrual Cycle." European Journal of Clinical Pharmacology, vol. 50, no. 3, 1996, pp. 179-84.
Moller SE, Moller BM, Olesen M, et al. Effects of oral contraceptives on plasma neutral amino acids and cholesterol during a menstrual cycle. Eur J Clin Pharmacol. 1996;50(3):179-84.
Moller, S. E., Moller, B. M., Olesen, M., & Fjalland, B. (1996). Effects of oral contraceptives on plasma neutral amino acids and cholesterol during a menstrual cycle. European Journal of Clinical Pharmacology, 50(3), 179-84.
Moller SE, et al. Effects of Oral Contraceptives On Plasma Neutral Amino Acids and Cholesterol During a Menstrual Cycle. Eur J Clin Pharmacol. 1996;50(3):179-84. PubMed PMID: 8737756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of oral contraceptives on plasma neutral amino acids and cholesterol during a menstrual cycle. AU - Moller,S E, AU - Moller,B M, AU - Olesen,M, AU - Fjalland,B, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez KW - Biology KW - Cholesterol KW - Comparative Studies KW - Contraception KW - Contraceptive Methods KW - Denmark KW - Developed Countries KW - Europe KW - Family Planning KW - Lipid Metabolic Effects KW - Lipids KW - Menstrual Cycle KW - Menstruation KW - Northern Europe KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Phasic KW - Physiology KW - Proteins KW - Reproduction KW - Research Methodology KW - Research Report KW - Scandinavia KW - Studies SP - 179 EP - 84 JF - European journal of clinical pharmacology JO - Eur J Clin Pharmacol VL - 50 IS - 3 N2 - OBJECTIVE: Concentrations of plasma neutral amino acids, i.e. threonine, serine, asparagine, glycine, alanine, citrulline, alpha-aminobutyric acid, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, and tryptophan, and serum cholesterol, were determined at the follicular (Day 4), mid-cycle (Day 16) and luteal (Day 25) phases of the menstrual cycle in 15 users of the new generation of combined oral contraceptives (OC), 11 on multiphase combined OC, and 17 controls. RESULTS: The controls showed a decrease in the sum of amino acids to 95% at mid-cycle and 90% in the luteal phase relative to the follicular phase, and a significant decrease in the tyrosine level at the luteal relative to the follicular phase. Since there was no significant difference between the two OC subgroups in the levels of the specified variables at either of the phases, the two groups were considered together. The sum of amino acids in the OC group decreased to 89% at mid-cycle and 91% at the luteal phase relative to the follicular phase, indicating less metabolic effect than reported for older OC formulations. Compared to the controls, the OC group showed significant increased threonine level at the luteal phase, decreased glycine levels at mid-cycle and the luteal phases, decreased citrulline level at mid-cycle, and markedly decreased tyrosine levels at the mid-cycle and luteal phases. Neither total nor high density lipoprotein (HDL) cholesterol differed significantly between the control and OC groups. CONCLUSION: The results suggest that the metabolic effects of the new generation combined OC on neutral amino acids and cholesterol are only modest to slight, except for the effect on tyrosine, the brain noradrenaline precursor, which may cause disturbances of various noradrenaline-mediated central functions in susceptible subjects. SN - 0031-6970 UR - https://www.unboundmedicine.com/medline/citation/8737756/Effects_of_oral_contraceptives_on_plasma_neutral_amino_acids_and_cholesterol_during_a_menstrual_cycle_ L2 - https://dx.doi.org/10.1007/s002280050089 DB - PRIME DP - Unbound Medicine ER -