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A quantitative comparison of plaque types in Alzheimer's disease and senile dementia of the Lewy body type.
Acta Neuropathol. 1996; 91(5):526-9.AN

Abstract

In a previous study we reported no difference in the overall beta-amyloid protein (beta AP) load between Alzheimer's disease (AD) and senile dementia of the Lewy body type (SDLT). However, it is possible that differences in the morphology of beta AP plaque types exist, analogous to the differences in cytoskeletal pathology found in these two disorders. We have carried out a quantitative image analysis of plaque subtypes in the temporal lobe of AD (n = 8), SDLT (n = 9) and control (n = 11) cases. Measurements of beta AP load and plaque density were consistently higher in AD and SDLT than in controls. When AD and SDLT cases were compared no differences were seen in either the density or relative proportions of classic and diffuse plaques. Based on these results we suggest that the variation in the clinical course of these diseases reflects differences in the cytoskeletal pathology, whereas the final stages of profound dementia common to both disorders is associated with the deposition of beta AP.

Authors+Show Affiliations

Department of Psychiatry, Charing Cross and Westminster Medical School, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8740234

Citation

McKenzie, J E., et al. "A Quantitative Comparison of Plaque Types in Alzheimer's Disease and Senile Dementia of the Lewy Body Type." Acta Neuropathologica, vol. 91, no. 5, 1996, pp. 526-9.
McKenzie JE, Edwards RJ, Gentleman SM, et al. A quantitative comparison of plaque types in Alzheimer's disease and senile dementia of the Lewy body type. Acta Neuropathol. 1996;91(5):526-9.
McKenzie, J. E., Edwards, R. J., Gentleman, S. M., Ince, P. G., Perry, R. H., Royston, M. C., & Roberts, G. W. (1996). A quantitative comparison of plaque types in Alzheimer's disease and senile dementia of the Lewy body type. Acta Neuropathologica, 91(5), 526-9.
McKenzie JE, et al. A Quantitative Comparison of Plaque Types in Alzheimer's Disease and Senile Dementia of the Lewy Body Type. Acta Neuropathol. 1996;91(5):526-9. PubMed PMID: 8740234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A quantitative comparison of plaque types in Alzheimer's disease and senile dementia of the Lewy body type. AU - McKenzie,J E, AU - Edwards,R J, AU - Gentleman,S M, AU - Ince,P G, AU - Perry,R H, AU - Royston,M C, AU - Roberts,G W, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 526 EP - 9 JF - Acta neuropathologica JO - Acta Neuropathol VL - 91 IS - 5 N2 - In a previous study we reported no difference in the overall beta-amyloid protein (beta AP) load between Alzheimer's disease (AD) and senile dementia of the Lewy body type (SDLT). However, it is possible that differences in the morphology of beta AP plaque types exist, analogous to the differences in cytoskeletal pathology found in these two disorders. We have carried out a quantitative image analysis of plaque subtypes in the temporal lobe of AD (n = 8), SDLT (n = 9) and control (n = 11) cases. Measurements of beta AP load and plaque density were consistently higher in AD and SDLT than in controls. When AD and SDLT cases were compared no differences were seen in either the density or relative proportions of classic and diffuse plaques. Based on these results we suggest that the variation in the clinical course of these diseases reflects differences in the cytoskeletal pathology, whereas the final stages of profound dementia common to both disorders is associated with the deposition of beta AP. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/8740234/A_quantitative_comparison_of_plaque_types_in_Alzheimer's_disease_and_senile_dementia_of_the_Lewy_body_type_ L2 - https://dx.doi.org/10.1007/s004010050461 DB - PRIME DP - Unbound Medicine ER -