Tags

Type your tag names separated by a space and hit enter

Diet and cancers of the larynx and hypopharynx: the IARC multi-center study in southwestern Europe.
Cancer Causes Control. 1996 Mar; 7(2):240-52.CC

Abstract

The main causes of cancer of the larynx and hypopharynx are smoking cigarettes and drinking alcohol. However, for these as well as for other cancers of the upper aerodigestive tract, some dietary components, mainly low consumption of fruit and vegetables, have been observed to be associated with increased cancer risk. We report results from a multicenter case-control study carried out in six regions of Europe located in northern Spain, northern Italy, Switzerland, and France. A total of 1,147 males with cancer (cases) and 3,057 population controls were interviewed on usual diet, lifelong drinking and smoking habits, and occupational history. Cancer cases had histologically verified epidermoid carcinomas. The cancers were classified in two anatomic sub-entities: the epilarynx (hypopharynx and upper part of the larynx), which enters into contact with the bolus and the air; and the endolarynx, through which air and tobacco smoke pass, but not the bolus. A previous report from this study found that alcohol drinking presents a greater risk factor for cancer of the epilarynx than for cancer of the endolarynx. The main results regarding diet indicate that high intake of fruit, vegetables, vegetable oil, fish, and low intake of butter and preserved meats were associated with reduced risk of both epilaryngeal and endolaryngeal cancers, after adjustment for alcohol, tobacco, socioeconomic status, and non-alcohol energy intake. Among nutrients, a reduced risk was found for high intake of vitamins C and E and for a high polyunsaturated/saturated fatty acids (P/S) ratio. While these variables are relevant in scoring nutritional behaviour, it remains unresolved whether the biologic properties of these nutrients play a role in the apparent protective effect.

Authors+Show Affiliations

International Agency for Research on Cancer, Lyon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8740737

Citation

Estève, J, et al. "Diet and Cancers of the Larynx and Hypopharynx: the IARC Multi-center Study in Southwestern Europe." Cancer Causes & Control : CCC, vol. 7, no. 2, 1996, pp. 240-52.
Estève J, Riboli E, Péquignot G, et al. Diet and cancers of the larynx and hypopharynx: the IARC multi-center study in southwestern Europe. Cancer Causes Control. 1996;7(2):240-52.
Estève, J., Riboli, E., Péquignot, G., Terracini, B., Merletti, F., Crosignani, P., Ascunce, N., Zubiri, L., Blanchet, F., Raymond, L., Repetto, F., & Tuyns, A. J. (1996). Diet and cancers of the larynx and hypopharynx: the IARC multi-center study in southwestern Europe. Cancer Causes & Control : CCC, 7(2), 240-52.
Estève J, et al. Diet and Cancers of the Larynx and Hypopharynx: the IARC Multi-center Study in Southwestern Europe. Cancer Causes Control. 1996;7(2):240-52. PubMed PMID: 8740737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet and cancers of the larynx and hypopharynx: the IARC multi-center study in southwestern Europe. AU - Estève,J, AU - Riboli,E, AU - Péquignot,G, AU - Terracini,B, AU - Merletti,F, AU - Crosignani,P, AU - Ascunce,N, AU - Zubiri,L, AU - Blanchet,F, AU - Raymond,L, AU - Repetto,F, AU - Tuyns,A J, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 240 EP - 52 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 7 IS - 2 N2 - The main causes of cancer of the larynx and hypopharynx are smoking cigarettes and drinking alcohol. However, for these as well as for other cancers of the upper aerodigestive tract, some dietary components, mainly low consumption of fruit and vegetables, have been observed to be associated with increased cancer risk. We report results from a multicenter case-control study carried out in six regions of Europe located in northern Spain, northern Italy, Switzerland, and France. A total of 1,147 males with cancer (cases) and 3,057 population controls were interviewed on usual diet, lifelong drinking and smoking habits, and occupational history. Cancer cases had histologically verified epidermoid carcinomas. The cancers were classified in two anatomic sub-entities: the epilarynx (hypopharynx and upper part of the larynx), which enters into contact with the bolus and the air; and the endolarynx, through which air and tobacco smoke pass, but not the bolus. A previous report from this study found that alcohol drinking presents a greater risk factor for cancer of the epilarynx than for cancer of the endolarynx. The main results regarding diet indicate that high intake of fruit, vegetables, vegetable oil, fish, and low intake of butter and preserved meats were associated with reduced risk of both epilaryngeal and endolaryngeal cancers, after adjustment for alcohol, tobacco, socioeconomic status, and non-alcohol energy intake. Among nutrients, a reduced risk was found for high intake of vitamins C and E and for a high polyunsaturated/saturated fatty acids (P/S) ratio. While these variables are relevant in scoring nutritional behaviour, it remains unresolved whether the biologic properties of these nutrients play a role in the apparent protective effect. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/8740737/Diet_and_cancers_of_the_larynx_and_hypopharynx:_the_IARC_multi_center_study_in_southwestern_Europe_ DB - PRIME DP - Unbound Medicine ER -