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Phenobarbital in the anticonvulsant dose range does not impair learning and memory or alter brain AChE activity or monoamine levels.
Pharmacol Biochem Behav 1996; 54(3):633-8PB

Abstract

The learning and memory in adult, male Wistar rats were assessed using the T-maze and passive avoidance tests after chronic administration of phenobarbital (PB) at 5, 15, 30, 60, or 75 mg/kg intraperitoneally (IP) for 21 days. The PB levels in plasma, the acetylcholine esterase (AChE) activity in the motor cortex, pyriform cortex, olfactory bulb, striatum, septum, and hippocampus and the levels of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) levels in the hippocampus were measured. There was no significant change in learning and memory, AChE activity, or monoamine levels at plasma PB levels of 1.5, 6.0, 9.0, and 25 micrograms/ml (corresponding to doses of 5, 15, 30, or 60 mg/kg PB, respectively). However, at a plasma level of 55 micrograms/ml (75 mg/kg), PB caused impairment in learning and memory. It was associated with an increase in AChE activity and 5-HT levels in the hippocampus. The results indicate that chronic PB administration may not be linked to impaired learning and memory functions at doses used in anticonvulsant therapy.

Authors+Show Affiliations

Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8743640

Citation

Sudha, S, et al. "Phenobarbital in the Anticonvulsant Dose Range Does Not Impair Learning and Memory or Alter Brain AChE Activity or Monoamine Levels." Pharmacology, Biochemistry, and Behavior, vol. 54, no. 3, 1996, pp. 633-8.
Sudha S, Lakshmana MK, Pradhan N. Phenobarbital in the anticonvulsant dose range does not impair learning and memory or alter brain AChE activity or monoamine levels. Pharmacol Biochem Behav. 1996;54(3):633-8.
Sudha, S., Lakshmana, M. K., & Pradhan, N. (1996). Phenobarbital in the anticonvulsant dose range does not impair learning and memory or alter brain AChE activity or monoamine levels. Pharmacology, Biochemistry, and Behavior, 54(3), pp. 633-8.
Sudha S, Lakshmana MK, Pradhan N. Phenobarbital in the Anticonvulsant Dose Range Does Not Impair Learning and Memory or Alter Brain AChE Activity or Monoamine Levels. Pharmacol Biochem Behav. 1996;54(3):633-8. PubMed PMID: 8743640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phenobarbital in the anticonvulsant dose range does not impair learning and memory or alter brain AChE activity or monoamine levels. AU - Sudha,S, AU - Lakshmana,M K, AU - Pradhan,N, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez SP - 633 EP - 8 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 54 IS - 3 N2 - The learning and memory in adult, male Wistar rats were assessed using the T-maze and passive avoidance tests after chronic administration of phenobarbital (PB) at 5, 15, 30, 60, or 75 mg/kg intraperitoneally (IP) for 21 days. The PB levels in plasma, the acetylcholine esterase (AChE) activity in the motor cortex, pyriform cortex, olfactory bulb, striatum, septum, and hippocampus and the levels of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) levels in the hippocampus were measured. There was no significant change in learning and memory, AChE activity, or monoamine levels at plasma PB levels of 1.5, 6.0, 9.0, and 25 micrograms/ml (corresponding to doses of 5, 15, 30, or 60 mg/kg PB, respectively). However, at a plasma level of 55 micrograms/ml (75 mg/kg), PB caused impairment in learning and memory. It was associated with an increase in AChE activity and 5-HT levels in the hippocampus. The results indicate that chronic PB administration may not be linked to impaired learning and memory functions at doses used in anticonvulsant therapy. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/8743640/Phenobarbital_in_the_anticonvulsant_dose_range_does_not_impair_learning_and_memory_or_alter_brain_AChE_activity_or_monoamine_levels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-3057(95)02283-X DB - PRIME DP - Unbound Medicine ER -