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A case of linear IgA bullous dermatosis with IgA anti-type VII collagen autoantibodies.
Br J Dermatol. 1996 Feb; 134(2):336-9.BJ

Abstract

In this study we present a patient with the sublamina densa type of linear IgA bullous dermatosis (LABD), with IgA autoantibodies reactive with the 290-kDa type VII collagen (the epidermolysis bullosa acquisita (EBA) antigen) and with immunoblotting of normal human dermal extracts. The clinical and histological features of the present case were compatible with those of LABD but quite different from those of EBA. Although EBA sera reacted with the bacterial fusion protein of the N-terminal globular (NC1) domain of type VII collagen, this patient's serum did not show reactivity. Furthermore, ultrastructural localization of target epitopes on the anchoring fibrils in this patient was considerably different from EBA. These results indicate that, whereas EBA antibodies react with the NC1 domain of type VII collagen, the epitope in this case is different from that of EBA (and is most likely on the central triple helical domain). This difference may be responsible for the clinical presentation in this patient being distinct from that of EBA.

Authors+Show Affiliations

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8746352

Citation

Hashimoto, T, et al. "A Case of Linear IgA Bullous Dermatosis With IgA Anti-type VII Collagen Autoantibodies." The British Journal of Dermatology, vol. 134, no. 2, 1996, pp. 336-9.
Hashimoto T, Ishiko A, Shimizu H, et al. A case of linear IgA bullous dermatosis with IgA anti-type VII collagen autoantibodies. Br J Dermatol. 1996;134(2):336-9.
Hashimoto, T., Ishiko, A., Shimizu, H., Tanaka, T., Dodd, H. J., Bhogal, B. S., Black, M. M., & Nishikawa, T. (1996). A case of linear IgA bullous dermatosis with IgA anti-type VII collagen autoantibodies. The British Journal of Dermatology, 134(2), 336-9.
Hashimoto T, et al. A Case of Linear IgA Bullous Dermatosis With IgA Anti-type VII Collagen Autoantibodies. Br J Dermatol. 1996;134(2):336-9. PubMed PMID: 8746352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of linear IgA bullous dermatosis with IgA anti-type VII collagen autoantibodies. AU - Hashimoto,T, AU - Ishiko,A, AU - Shimizu,H, AU - Tanaka,T, AU - Dodd,H J, AU - Bhogal,B S, AU - Black,M M, AU - Nishikawa,T, PY - 1996/2/1/pubmed PY - 1996/2/1/medline PY - 1996/2/1/entrez SP - 336 EP - 9 JF - The British journal of dermatology JO - Br J Dermatol VL - 134 IS - 2 N2 - In this study we present a patient with the sublamina densa type of linear IgA bullous dermatosis (LABD), with IgA autoantibodies reactive with the 290-kDa type VII collagen (the epidermolysis bullosa acquisita (EBA) antigen) and with immunoblotting of normal human dermal extracts. The clinical and histological features of the present case were compatible with those of LABD but quite different from those of EBA. Although EBA sera reacted with the bacterial fusion protein of the N-terminal globular (NC1) domain of type VII collagen, this patient's serum did not show reactivity. Furthermore, ultrastructural localization of target epitopes on the anchoring fibrils in this patient was considerably different from EBA. These results indicate that, whereas EBA antibodies react with the NC1 domain of type VII collagen, the epitope in this case is different from that of EBA (and is most likely on the central triple helical domain). This difference may be responsible for the clinical presentation in this patient being distinct from that of EBA. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/8746352/A_case_of_linear_IgA_bullous_dermatosis_with_IgA_anti_type_VII_collagen_autoantibodies_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=1996&volume=134&issue=2&spage=336 DB - PRIME DP - Unbound Medicine ER -