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Apomorphine continuous stimulation in Parkinson's disease: receptor desensitization as a possible mechanism of reduced motor response.
J Neural Transm Suppl. 1995; 45:133-6.JN

Abstract

Apomorphine is a potent nonselective agonist at D1 and D2 dopamine receptors. The utility of apomorphine in Parkinson's disease (PD) is well asserted but its clinical use is reduced because of its short half-life and numerous side-effects. The disabling "on-off" fluctuations are among the most frequent and troublesome complications of chronic levodopa therapy in PD. Apomorphine is effective to reverse refractory L-dopa induced "off" periods, but a reduced motor response after repeated administrations has also been described with this drug. The loss of response to apomorphine, when the drug is administered repeatedly, is well fitted by the processes of receptor phosphorylation and down regulation. Elucidation of the molecular bases of dopaminergic receptors desensitization may lead to a better understanding of the mechanisms of dopaminergic regulation, and to a more appropriate treatment of PD.

Authors+Show Affiliations

Istituto di Farmacologia, Scuola Medica, Università di Pisa, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

8748618

Citation

Maggio, R, et al. "Apomorphine Continuous Stimulation in Parkinson's Disease: Receptor Desensitization as a Possible Mechanism of Reduced Motor Response." Journal of Neural Transmission. Supplementum, vol. 45, 1995, pp. 133-6.
Maggio R, Barbier P, Corsini GU. Apomorphine continuous stimulation in Parkinson's disease: receptor desensitization as a possible mechanism of reduced motor response. J Neural Transm Suppl. 1995;45:133-6.
Maggio, R., Barbier, P., & Corsini, G. U. (1995). Apomorphine continuous stimulation in Parkinson's disease: receptor desensitization as a possible mechanism of reduced motor response. Journal of Neural Transmission. Supplementum, 45, 133-6.
Maggio R, Barbier P, Corsini GU. Apomorphine Continuous Stimulation in Parkinson's Disease: Receptor Desensitization as a Possible Mechanism of Reduced Motor Response. J Neural Transm Suppl. 1995;45:133-6. PubMed PMID: 8748618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apomorphine continuous stimulation in Parkinson's disease: receptor desensitization as a possible mechanism of reduced motor response. AU - Maggio,R, AU - Barbier,P, AU - Corsini,G U, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 133 EP - 6 JF - Journal of neural transmission. Supplementum JO - J Neural Transm Suppl VL - 45 N2 - Apomorphine is a potent nonselective agonist at D1 and D2 dopamine receptors. The utility of apomorphine in Parkinson's disease (PD) is well asserted but its clinical use is reduced because of its short half-life and numerous side-effects. The disabling "on-off" fluctuations are among the most frequent and troublesome complications of chronic levodopa therapy in PD. Apomorphine is effective to reverse refractory L-dopa induced "off" periods, but a reduced motor response after repeated administrations has also been described with this drug. The loss of response to apomorphine, when the drug is administered repeatedly, is well fitted by the processes of receptor phosphorylation and down regulation. Elucidation of the molecular bases of dopaminergic receptors desensitization may lead to a better understanding of the mechanisms of dopaminergic regulation, and to a more appropriate treatment of PD. SN - 0303-6995 UR - https://www.unboundmedicine.com/medline/citation/8748618/Apomorphine_continuous_stimulation_in_Parkinson's_disease:_receptor_desensitization_as_a_possible_mechanism_of_reduced_motor_response_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -