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The role of L-threo DOPS in the control of Na-K ATPase activity of the marginal cells in the stria vascularis of reserpinized guinea pigs.
Acta Otolaryngol Suppl. 1995; 520 Pt 2:381-3.AO

Abstract

It is believed that the function of the stria vascularis in the cochlea is to produce endolymph. The mechanisms that maintain or control the function of the stria vascularis, however, remain unclear. In a previous study, we investigated the ultracytochemical effects of one-shot reserpine administration on the Na-K ATPase activity of the stria vascularis in guinea pigs. Na-K ATPase activity was shown to be completely inhibited 3-20 days after reserpinization, whereas in the present study at 20 days after reserpinization and following L-threo DOPS treatment, Na-K ATPase activity was detectable. As reserpine is an adrenergic neuron blocker, and L-threo DOPS is the precursor of noradrenaline, it seems that noradrenaline converted from L-threo DOPS was able to restore the Na-K ATPase activity in the reserpinized animals. These results suggest that catecholamines may play an essential role in the maintenance or control of the Na-K ATPase activity, and that the stria vascularis may be one of the target organs of catecholamines.

Authors+Show Affiliations

Department of Otolaryngology, Hyogo College of Medicine, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8749167

Citation

Kanoh, N, and J Nomura. "The Role of L-threo DOPS in the Control of Na-K ATPase Activity of the Marginal Cells in the Stria Vascularis of Reserpinized Guinea Pigs." Acta Oto-laryngologica. Supplementum, vol. 520 Pt 2, 1995, pp. 381-3.
Kanoh N, Nomura J. The role of L-threo DOPS in the control of Na-K ATPase activity of the marginal cells in the stria vascularis of reserpinized guinea pigs. Acta Otolaryngol Suppl. 1995;520 Pt 2:381-3.
Kanoh, N., & Nomura, J. (1995). The role of L-threo DOPS in the control of Na-K ATPase activity of the marginal cells in the stria vascularis of reserpinized guinea pigs. Acta Oto-laryngologica. Supplementum, 520 Pt 2, 381-3.
Kanoh N, Nomura J. The Role of L-threo DOPS in the Control of Na-K ATPase Activity of the Marginal Cells in the Stria Vascularis of Reserpinized Guinea Pigs. Acta Otolaryngol Suppl. 1995;520 Pt 2:381-3. PubMed PMID: 8749167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of L-threo DOPS in the control of Na-K ATPase activity of the marginal cells in the stria vascularis of reserpinized guinea pigs. AU - Kanoh,N, AU - Nomura,J, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 381 EP - 3 JF - Acta oto-laryngologica. Supplementum JO - Acta Otolaryngol Suppl VL - 520 Pt 2 N2 - It is believed that the function of the stria vascularis in the cochlea is to produce endolymph. The mechanisms that maintain or control the function of the stria vascularis, however, remain unclear. In a previous study, we investigated the ultracytochemical effects of one-shot reserpine administration on the Na-K ATPase activity of the stria vascularis in guinea pigs. Na-K ATPase activity was shown to be completely inhibited 3-20 days after reserpinization, whereas in the present study at 20 days after reserpinization and following L-threo DOPS treatment, Na-K ATPase activity was detectable. As reserpine is an adrenergic neuron blocker, and L-threo DOPS is the precursor of noradrenaline, it seems that noradrenaline converted from L-threo DOPS was able to restore the Na-K ATPase activity in the reserpinized animals. These results suggest that catecholamines may play an essential role in the maintenance or control of the Na-K ATPase activity, and that the stria vascularis may be one of the target organs of catecholamines. SN - 0365-5237 UR - https://www.unboundmedicine.com/medline/citation/8749167/The_role_of_L_threo_DOPS_in_the_control_of_Na_K_ATPase_activity_of_the_marginal_cells_in_the_stria_vascularis_of_reserpinized_guinea_pigs_ DB - PRIME DP - Unbound Medicine ER -