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Abnormally phosphorylated tau protein in senile dementia of Lewy body type and Alzheimer disease: evidence that the disorders are distinct.
Alzheimer Dis Assoc Disord. 1995 Winter; 9(4):218-22.AD

Abstract

The relationship between Alzheimer disease (AD) and dementia with Lewy bodies (senile dementia Lewy body type, or SDLT) and dementia in Parkinson's disease is unclear. AD pathology is characterised by both amyloid deposition and abnormal phosphorylation of tau in paired helical filaments (PHF-tau). In AD, abnormally phosphorylated PHF-tau is present in neurofibrillary tangles, in neuritic processes of senile plaques, and also in neuropil threads dispersed throughout the cerebral cortex. Cortical homogenates from 12 cases each of AD and SDLT, 13 cases of Parkinson's disease, and 11 normal controls were examined by Western blot analysis with antibodies that detect PHF-tau. No PHF-tau was found in Parkinson's disease or control cortex. No PHF-tau was found in SDLT cases without histological evidence of tangles. PHF-tau was detectable in SDLT cases with a low density of tangles, and large amounts of PHF-tau were present in AD cases. This study demonstrates that abnormally phosphorylated PHF-tau is only present where tangles are found and not in SDLT cases without tangles or with only occasional tangles. It is concluded that Lewy body dementias are distinct at a molecular level from AD.

Authors+Show Affiliations

Neurodegenerative Diseases Research Group, Institute of Psychiatry, London, England.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8749611

Citation

Strong, C, et al. "Abnormally Phosphorylated Tau Protein in Senile Dementia of Lewy Body Type and Alzheimer Disease: Evidence That the Disorders Are Distinct." Alzheimer Disease and Associated Disorders, vol. 9, no. 4, 1995, pp. 218-22.
Strong C, Anderton BH, Perry RH, et al. Abnormally phosphorylated tau protein in senile dementia of Lewy body type and Alzheimer disease: evidence that the disorders are distinct. Alzheimer Dis Assoc Disord. 1995;9(4):218-22.
Strong, C., Anderton, B. H., Perry, R. H., Perry, E. K., Ince, P. G., & Lovestone, S. (1995). Abnormally phosphorylated tau protein in senile dementia of Lewy body type and Alzheimer disease: evidence that the disorders are distinct. Alzheimer Disease and Associated Disorders, 9(4), 218-22.
Strong C, et al. Abnormally Phosphorylated Tau Protein in Senile Dementia of Lewy Body Type and Alzheimer Disease: Evidence That the Disorders Are Distinct. Alzheimer Dis Assoc Disord. 1995;9(4):218-22. PubMed PMID: 8749611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormally phosphorylated tau protein in senile dementia of Lewy body type and Alzheimer disease: evidence that the disorders are distinct. AU - Strong,C, AU - Anderton,B H, AU - Perry,R H, AU - Perry,E K, AU - Ince,P G, AU - Lovestone,S, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 218 EP - 22 JF - Alzheimer disease and associated disorders JO - Alzheimer Dis Assoc Disord VL - 9 IS - 4 N2 - The relationship between Alzheimer disease (AD) and dementia with Lewy bodies (senile dementia Lewy body type, or SDLT) and dementia in Parkinson's disease is unclear. AD pathology is characterised by both amyloid deposition and abnormal phosphorylation of tau in paired helical filaments (PHF-tau). In AD, abnormally phosphorylated PHF-tau is present in neurofibrillary tangles, in neuritic processes of senile plaques, and also in neuropil threads dispersed throughout the cerebral cortex. Cortical homogenates from 12 cases each of AD and SDLT, 13 cases of Parkinson's disease, and 11 normal controls were examined by Western blot analysis with antibodies that detect PHF-tau. No PHF-tau was found in Parkinson's disease or control cortex. No PHF-tau was found in SDLT cases without histological evidence of tangles. PHF-tau was detectable in SDLT cases with a low density of tangles, and large amounts of PHF-tau were present in AD cases. This study demonstrates that abnormally phosphorylated PHF-tau is only present where tangles are found and not in SDLT cases without tangles or with only occasional tangles. It is concluded that Lewy body dementias are distinct at a molecular level from AD. SN - 0893-0341 UR - https://www.unboundmedicine.com/medline/citation/8749611/Abnormally_phosphorylated_tau_protein_in_senile_dementia_of_Lewy_body_type_and_Alzheimer_disease:_evidence_that_the_disorders_are_distinct_ DB - PRIME DP - Unbound Medicine ER -