Tags

Type your tag names separated by a space and hit enter

Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I.
Biol Psychiatry. 1995 Dec 15; 38(12):797-802.BP

Abstract

Hypothalamic-pituitary-adrenal system (HPA)-function in patients with mania (n = 11), depression (n = 11, unipolar) and in control subjects (n = 11) was studied; six of the acutely manic patients were reevaluated after a symptom-free interval of at least 6 months. The combined dexamethasone-suppression/human CRH-challenge test was used to probe HPA-system function. After CRH and dexamethasone pretreatment, ACTH and cortisol release were significantly increased in both manic and depressed patients in comparison to the control group. In the remitted patients with mania, a significant decrease in hormonal release after DEX and CRH was evident when compared to the acute manic episode, but the degree of CRH-stimulated hormone secretion in these remitted patients was still significantly larger than in normal controls. This study demonstrates that acute and remitted manic episodes are associated with a profoundly dysregulated HPA-system activity.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8750037

Citation

Schmider, J, et al. "Combined Dexamethasone/corticotropin-releasing Hormone Test in Acute and Remitted Manic Patients, in Acute Depression, and in Normal Controls: I." Biological Psychiatry, vol. 38, no. 12, 1995, pp. 797-802.
Schmider J, Lammers CH, Gotthardt U, et al. Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I. Biol Psychiatry. 1995;38(12):797-802.
Schmider, J., Lammers, C. H., Gotthardt, U., Dettling, M., Holsboer, F., & Heuser, I. J. (1995). Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I. Biological Psychiatry, 38(12), 797-802.
Schmider J, et al. Combined Dexamethasone/corticotropin-releasing Hormone Test in Acute and Remitted Manic Patients, in Acute Depression, and in Normal Controls: I. Biol Psychiatry. 1995 Dec 15;38(12):797-802. PubMed PMID: 8750037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I. AU - Schmider,J, AU - Lammers,C H, AU - Gotthardt,U, AU - Dettling,M, AU - Holsboer,F, AU - Heuser,I J, PY - 1995/12/15/pubmed PY - 1995/12/15/medline PY - 1995/12/15/entrez SP - 797 EP - 802 JF - Biological psychiatry JO - Biol Psychiatry VL - 38 IS - 12 N2 - Hypothalamic-pituitary-adrenal system (HPA)-function in patients with mania (n = 11), depression (n = 11, unipolar) and in control subjects (n = 11) was studied; six of the acutely manic patients were reevaluated after a symptom-free interval of at least 6 months. The combined dexamethasone-suppression/human CRH-challenge test was used to probe HPA-system function. After CRH and dexamethasone pretreatment, ACTH and cortisol release were significantly increased in both manic and depressed patients in comparison to the control group. In the remitted patients with mania, a significant decrease in hormonal release after DEX and CRH was evident when compared to the acute manic episode, but the degree of CRH-stimulated hormone secretion in these remitted patients was still significantly larger than in normal controls. This study demonstrates that acute and remitted manic episodes are associated with a profoundly dysregulated HPA-system activity. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/8750037/Combined_dexamethasone/corticotropin_releasing_hormone_test_in_acute_and_remitted_manic_patients_in_acute_depression_and_in_normal_controls:_I_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-3223(95)00064-X DB - PRIME DP - Unbound Medicine ER -