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Herpes simplex virus-inhibitory sulfated xylogalactans from the red seaweed Nothogenia fastigiata.
Chemotherapy. 1996 Jan-Feb; 42(1):57-64.C

Abstract

Two sulfated xylogalactans (F1 and F7), isolated from the red seaweed Nothogenia fastigiata, achieved a dose-dependent inhibition of the replication of herpes simplex virus type 1 (HSV-1) in Vero cells, with 50% effective doses in the range of 15.0-32.6 micrograms/ml, and without affecting cell viability at concentrations up to 200 micrograms/ml. The presence of sulfate groups in the molecule was essential for the antiviral properties of these polysaccharides. F7 afforded significant inhibition in HSV-1 yield if added to the cell cultures simultaneously with virus inoculum, but had no effect when it was added after 1 h of infection. Analysis of the early events of the viral replicative cycle showed that the anti-HSV effect of F7 was due to a specific inhibition of virus attachment to the host cell whereas virus internalization was not impaired.

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Authors+Show Affiliations

Damonte EB
Departamento de Química Biológica, Universidad de Buenos Aires, Argentina.
Matulewicz MC
No affiliation info available
Cerezo AS
No affiliation info available
Coto CE
No affiliation info available

MeSH

AnimalsAntiviral AgentsChlorocebus aethiopsGalactansHerpesvirus 1, HumanSeaweedVero Cells

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8751267

Citation

Damonte, E B., et al. "Herpes Simplex Virus-inhibitory Sulfated Xylogalactans From the Red Seaweed Nothogenia Fastigiata." Chemotherapy, vol. 42, no. 1, 1996, pp. 57-64.
Damonte EB, Matulewicz MC, Cerezo AS, et al. Herpes simplex virus-inhibitory sulfated xylogalactans from the red seaweed Nothogenia fastigiata. Chemotherapy. 1996;42(1):57-64.
Damonte, E. B., Matulewicz, M. C., Cerezo, A. S., & Coto, C. E. (1996). Herpes simplex virus-inhibitory sulfated xylogalactans from the red seaweed Nothogenia fastigiata. Chemotherapy, 42(1), 57-64.
Damonte EB, et al. Herpes Simplex Virus-inhibitory Sulfated Xylogalactans From the Red Seaweed Nothogenia Fastigiata. Chemotherapy. 1996 Jan-Feb;42(1):57-64. PubMed PMID: 8751267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Herpes simplex virus-inhibitory sulfated xylogalactans from the red seaweed Nothogenia fastigiata. AU - Damonte,E B, AU - Matulewicz,M C, AU - Cerezo,A S, AU - Coto,C E, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 57 EP - 64 JF - Chemotherapy JO - Chemotherapy VL - 42 IS - 1 N2 - Two sulfated xylogalactans (F1 and F7), isolated from the red seaweed Nothogenia fastigiata, achieved a dose-dependent inhibition of the replication of herpes simplex virus type 1 (HSV-1) in Vero cells, with 50% effective doses in the range of 15.0-32.6 micrograms/ml, and without affecting cell viability at concentrations up to 200 micrograms/ml. The presence of sulfate groups in the molecule was essential for the antiviral properties of these polysaccharides. F7 afforded significant inhibition in HSV-1 yield if added to the cell cultures simultaneously with virus inoculum, but had no effect when it was added after 1 h of infection. Analysis of the early events of the viral replicative cycle showed that the anti-HSV effect of F7 was due to a specific inhibition of virus attachment to the host cell whereas virus internalization was not impaired. SN - 0009-3157 UR - https://www.unboundmedicine.com/medline/citation/8751267/Herpes_simplex_virus_inhibitory_sulfated_xylogalactans_from_the_red_seaweed_Nothogenia_fastigiata_ L2 - https://www.karger.com?DOI=10.1159/000239422 DB - PRIME DP - Unbound Medicine ER -