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Hot flushes, menstrual status, and hormone levels in a population-based sample of midlife women.
Obstet Gynecol. 1996 Sep; 88(3):437-42.OG

Abstract

OBJECTIVE

To determine the frequency of hot flushes in a population sample of 453 pre-, peri-, and postmenopausal women (aged 48-59 years), and to investigate the relationship of hot-flush reporting with menstrual status, serum levels of estradiol (E2), inhibin, and FSH, history of premenstrual complaints, and physical and life-style factors.

METHODS

We used a population-based sample. Interviews were conducted in the women's homes.

RESULTS

Frequency of hot-flush reporting was associated with menstrual status (P < .001). Twenty-nine percent of women who had more than 3 and less than 12 months of amenorrhea, and 37% of postmenopausal women experienced hot flushes several times a day. In total, 13% of premenopausal women, 37% of perimenopausal women, 62% of postmenopausal women, and 15% of women on hormone therapy reported having had at least one hot flush in the previous 2 weeks. Follicle-stimulating hormone levels were higher in women who experienced hot flushes at least once a day or more (P < .001); E2 levels were higher in women experiencing one or no hot flushes per week (P < .001). The women in the perimenopausal group who experienced hot flushes had higher FSH levels (P = .008) and were more likely to have reported premenstrual complaints at the first interview 3 years earlier (P = .03). In the postmenopausal group, there was no significant difference with any of the variables studied between the women who were experiencing hot flushes and those who were not.

CONCLUSION

Reporting of hot flushes is greatest 3 months or more after the final menstrual period. The frequency of hot flushes is associated with increasing FSH, decreasing E2, and a history of premenstrual complaints.

Authors+Show Affiliations

Key Centre for Women's Health Services, Department of Public Health and Community Medicíne, University of Melbourne, Carlton, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8752255

Citation

Guthrie, J R., et al. "Hot Flushes, Menstrual Status, and Hormone Levels in a Population-based Sample of Midlife Women." Obstetrics and Gynecology, vol. 88, no. 3, 1996, pp. 437-42.
Guthrie JR, Dennerstein L, Hopper JL, et al. Hot flushes, menstrual status, and hormone levels in a population-based sample of midlife women. Obstet Gynecol. 1996;88(3):437-42.
Guthrie, J. R., Dennerstein, L., Hopper, J. L., & Burger, H. G. (1996). Hot flushes, menstrual status, and hormone levels in a population-based sample of midlife women. Obstetrics and Gynecology, 88(3), 437-42.
Guthrie JR, et al. Hot Flushes, Menstrual Status, and Hormone Levels in a Population-based Sample of Midlife Women. Obstet Gynecol. 1996;88(3):437-42. PubMed PMID: 8752255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hot flushes, menstrual status, and hormone levels in a population-based sample of midlife women. AU - Guthrie,J R, AU - Dennerstein,L, AU - Hopper,J L, AU - Burger,H G, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 437 EP - 42 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 88 IS - 3 N2 - OBJECTIVE: To determine the frequency of hot flushes in a population sample of 453 pre-, peri-, and postmenopausal women (aged 48-59 years), and to investigate the relationship of hot-flush reporting with menstrual status, serum levels of estradiol (E2), inhibin, and FSH, history of premenstrual complaints, and physical and life-style factors. METHODS: We used a population-based sample. Interviews were conducted in the women's homes. RESULTS: Frequency of hot-flush reporting was associated with menstrual status (P < .001). Twenty-nine percent of women who had more than 3 and less than 12 months of amenorrhea, and 37% of postmenopausal women experienced hot flushes several times a day. In total, 13% of premenopausal women, 37% of perimenopausal women, 62% of postmenopausal women, and 15% of women on hormone therapy reported having had at least one hot flush in the previous 2 weeks. Follicle-stimulating hormone levels were higher in women who experienced hot flushes at least once a day or more (P < .001); E2 levels were higher in women experiencing one or no hot flushes per week (P < .001). The women in the perimenopausal group who experienced hot flushes had higher FSH levels (P = .008) and were more likely to have reported premenstrual complaints at the first interview 3 years earlier (P = .03). In the postmenopausal group, there was no significant difference with any of the variables studied between the women who were experiencing hot flushes and those who were not. CONCLUSION: Reporting of hot flushes is greatest 3 months or more after the final menstrual period. The frequency of hot flushes is associated with increasing FSH, decreasing E2, and a history of premenstrual complaints. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/8752255/Hot_flushes_menstrual_status_and_hormone_levels_in_a_population_based_sample_of_midlife_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0029-7844(96)00196-2 DB - PRIME DP - Unbound Medicine ER -