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Immunohistochemical characterization of stromal leukocytes in ovarian endometriosis: comparison of eutopic and ectopic endometrium with normal endometrium.
Fertil Steril. 1996 Jul; 66(1):81-9.FS

Abstract

OBJECTIVE

To compare stromal leukocyte subpopulations in different phases of the menstrual cycle in eutopic and ectopic endometrium from women with ovarian endometriosis and in control endometrium.

DESIGN

Retrospective immunohistochemical study.

SETTING

Department of Pathology, Royal Victoria Infirmary, Newcastle-upon-Tyne, United Kingdom.

PATIENTS

Paraffin-embedded tissue blocks from 30 patients with endometriosis and 30 control blocks from patients undergoing hysterectomy for nonendometrial pathology were retrieved from archive files.

MAIN OUTCOME MEASURE

Quantitative assessment of defined stromal leukocyte subpopulations in eutopic, ectopic and control endometrium at different stages of the menstrual cycle.

RESULTS

In the proliferative and early secretory phases, ectopic endometrium contained elevated numbers of CD45+, CD3+, and CD43+ cells but reduced percentages of CD68+ macrophages. The proportions of granulated cells were reduced in ectopic endometrium throughout the cycle. No differences were noted between eutopic endometrium from women with endometriosis and control endometrium.

CONCLUSION

Differences between eutopic and ectopic leukocyte subpopulations with the exception of large granular lymphocytes may be due to the lack of cyclicity demonstrated by endometriotic lesions.

Authors+Show Affiliations

Department of Immunology, University of Newcastle, Medical School, Newcastle-upon-Tyne, United Kingdom.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8752615

Citation

Jones, R K., et al. "Immunohistochemical Characterization of Stromal Leukocytes in Ovarian Endometriosis: Comparison of Eutopic and Ectopic Endometrium With Normal Endometrium." Fertility and Sterility, vol. 66, no. 1, 1996, pp. 81-9.
Jones RK, Bulmer JN, Searle RF. Immunohistochemical characterization of stromal leukocytes in ovarian endometriosis: comparison of eutopic and ectopic endometrium with normal endometrium. Fertil Steril. 1996;66(1):81-9.
Jones, R. K., Bulmer, J. N., & Searle, R. F. (1996). Immunohistochemical characterization of stromal leukocytes in ovarian endometriosis: comparison of eutopic and ectopic endometrium with normal endometrium. Fertility and Sterility, 66(1), 81-9.
Jones RK, Bulmer JN, Searle RF. Immunohistochemical Characterization of Stromal Leukocytes in Ovarian Endometriosis: Comparison of Eutopic and Ectopic Endometrium With Normal Endometrium. Fertil Steril. 1996;66(1):81-9. PubMed PMID: 8752615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistochemical characterization of stromal leukocytes in ovarian endometriosis: comparison of eutopic and ectopic endometrium with normal endometrium. AU - Jones,R K, AU - Bulmer,J N, AU - Searle,R F, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez SP - 81 EP - 9 JF - Fertility and sterility JO - Fertil. Steril. VL - 66 IS - 1 N2 - OBJECTIVE: To compare stromal leukocyte subpopulations in different phases of the menstrual cycle in eutopic and ectopic endometrium from women with ovarian endometriosis and in control endometrium. DESIGN: Retrospective immunohistochemical study. SETTING: Department of Pathology, Royal Victoria Infirmary, Newcastle-upon-Tyne, United Kingdom. PATIENTS: Paraffin-embedded tissue blocks from 30 patients with endometriosis and 30 control blocks from patients undergoing hysterectomy for nonendometrial pathology were retrieved from archive files. MAIN OUTCOME MEASURE: Quantitative assessment of defined stromal leukocyte subpopulations in eutopic, ectopic and control endometrium at different stages of the menstrual cycle. RESULTS: In the proliferative and early secretory phases, ectopic endometrium contained elevated numbers of CD45+, CD3+, and CD43+ cells but reduced percentages of CD68+ macrophages. The proportions of granulated cells were reduced in ectopic endometrium throughout the cycle. No differences were noted between eutopic endometrium from women with endometriosis and control endometrium. CONCLUSION: Differences between eutopic and ectopic leukocyte subpopulations with the exception of large granular lymphocytes may be due to the lack of cyclicity demonstrated by endometriotic lesions. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/8752615/Immunohistochemical_characterization_of_stromal_leukocytes_in_ovarian_endometriosis:_comparison_of_eutopic_and_ectopic_endometrium_with_normal_endometrium_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(16)58391-5 DB - PRIME DP - Unbound Medicine ER -