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Laboratory criteria for menopause in women using oral contraceptives.
Fertil Steril. 1996 Jul; 66(1):101-4.FS

Abstract

OBJECTIVE

To evaluate laboratory criteria for menopause in women talking oral contraceptives (OC).

DESIGN

Prospective, uncontrolled pilot study.

SETTING

San Francisco General Hospital, San Francisco, California, and Magee-Womens Hospital, Pittsburgh, Pennsylvania.

PATIENTS

Twenty-eight menopausal women.

INTERVENTIONS

Fourteen menopausal women received triphasic 35 micrograms ethinyl E2 and 180-215-250 micrograms norgestimate, and 14 menopausal women received monophasic 30 micrograms ethinyl E2-150 micrograms desogestrel.

MAIN OUTCOME MEASURES

Serum FSH, LH, and E2 levels were evaluated on days 14 and 28 (day 7 of the pill-free interval) of the third cycle of pills.

RESULTS

Twelve women in each group completed the study. Fifteen (62.5%) subjects still had a serum FSH < 30 mIU/mL (30 IU/L) on the 7th day of the pill-free interval of the third pill package. All subjects had a serum FSH:LH ratio > 1 and 20 of 21 (95%) subjects had E2 < 20 pg/mL (73 pmol/L) at the end of the pill-free interval of the third cycle.

CONCLUSIONS

Measuring FSH on the 7th day of the pill-free interval is not a sensitive test for menopause. Serum FSH:LH ratio > 1 or E2 < 20 pg/mL (73 pmol/L) on the 7th day of the pill-free interval may be a more appropriate marker of menopause in women using OC in the later reproductive years.

Authors+Show Affiliations

University of Pittsburgh School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital, Pennsylvania 15213-3180, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8752618

Citation

Creinin, M D.. "Laboratory Criteria for Menopause in Women Using Oral Contraceptives." Fertility and Sterility, vol. 66, no. 1, 1996, pp. 101-4.
Creinin MD. Laboratory criteria for menopause in women using oral contraceptives. Fertil Steril. 1996;66(1):101-4.
Creinin, M. D. (1996). Laboratory criteria for menopause in women using oral contraceptives. Fertility and Sterility, 66(1), 101-4.
Creinin MD. Laboratory Criteria for Menopause in Women Using Oral Contraceptives. Fertil Steril. 1996;66(1):101-4. PubMed PMID: 8752618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laboratory criteria for menopause in women using oral contraceptives. A1 - Creinin,M D, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez KW - Americas KW - Biology KW - California KW - Comparative Studies KW - Contraception KW - Contraceptive Methods KW - Developed Countries KW - Endocrine System KW - Estradiol KW - Estrogens KW - Examinations And Diagnoses KW - Family Planning KW - Follicle Stimulating Hormone KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones KW - Laboratory Examinations And Diagnoses KW - Luteinizing Hormone KW - Menopause KW - North America KW - Northern America KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Phasic KW - Pennsylvania KW - Physiology KW - Reproduction KW - Research Methodology KW - Research Report KW - Studies KW - United States SP - 101 EP - 4 JF - Fertility and sterility JO - Fertil Steril VL - 66 IS - 1 N2 - OBJECTIVE: To evaluate laboratory criteria for menopause in women talking oral contraceptives (OC). DESIGN: Prospective, uncontrolled pilot study. SETTING: San Francisco General Hospital, San Francisco, California, and Magee-Womens Hospital, Pittsburgh, Pennsylvania. PATIENTS: Twenty-eight menopausal women. INTERVENTIONS: Fourteen menopausal women received triphasic 35 micrograms ethinyl E2 and 180-215-250 micrograms norgestimate, and 14 menopausal women received monophasic 30 micrograms ethinyl E2-150 micrograms desogestrel. MAIN OUTCOME MEASURES: Serum FSH, LH, and E2 levels were evaluated on days 14 and 28 (day 7 of the pill-free interval) of the third cycle of pills. RESULTS: Twelve women in each group completed the study. Fifteen (62.5%) subjects still had a serum FSH < 30 mIU/mL (30 IU/L) on the 7th day of the pill-free interval of the third pill package. All subjects had a serum FSH:LH ratio > 1 and 20 of 21 (95%) subjects had E2 < 20 pg/mL (73 pmol/L) at the end of the pill-free interval of the third cycle. CONCLUSIONS: Measuring FSH on the 7th day of the pill-free interval is not a sensitive test for menopause. Serum FSH:LH ratio > 1 or E2 < 20 pg/mL (73 pmol/L) on the 7th day of the pill-free interval may be a more appropriate marker of menopause in women using OC in the later reproductive years. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/8752618/Laboratory_criteria_for_menopause_in_women_using_oral_contraceptives_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(16)58394-0 DB - PRIME DP - Unbound Medicine ER -