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Opioid rotation in patients with cancer pain. A retrospective comparison of dose ratios between methadone, hydromorphone, and morphine.
Cancer. 1996 Aug 15; 78(4):852-7.C

Abstract

BACKGROUND

When a change of opioid is considered, equianalgesic dose tables are used. These tables generally propose a dose ratio of 5:1 between morphine and hydromorphone. In the case of a change from subcutaneous hydromorphone to methadone, dose ratios ranging from 1:6 to 1:10 are proposed. The purpose of this study was to review the analgesic dose ratios for methadone compared with hydromorphone.

METHODS

In a retrospective study, 48 cases of medication changes from morphine to hydromorphone, and 65 changes between hydromorphone and methadone were identified. the reason for the change, the analgesic dose, and pain intensity were obtained.

RESULTS

The dose ratios between morphine and hydromorphone and vice versa were found to be 5.33 and 0.28, respectively (similar to expected results). However, the hydromorphone/methadone ratio was found to be 1.14:1 (5 to 10 times higher than expected). Although the dose ratios of hydromorphone/morphine and vice versa did not change according to a previous opioid dose, the hydromorphone/methadone ratio correlated with total opioid dose (correlation coefficient = 0.41 P < 0.001) and was 1.6 (range, 0.3-14.4) in patients receiving more than 330 mg of hydromorphone per day prior to the change, versus 0.95 (range, 0.2-12.3) in patients receiving ae330 mg of hydromorphone per day (P = 0.023).

CONCLUSIONS

These results suggest that only partial tolerance develops between methadone and hydromorphone. Methadone is much more potent than previously described and any change should start at a lower equivalent dose.

Authors+Show Affiliations

Department of Medicine, University of Alberta, Edmonton, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8756381

Citation

Bruera, E, et al. "Opioid Rotation in Patients With Cancer Pain. a Retrospective Comparison of Dose Ratios Between Methadone, Hydromorphone, and Morphine." Cancer, vol. 78, no. 4, 1996, pp. 852-7.
Bruera E, Pereira J, Watanabe S, et al. Opioid rotation in patients with cancer pain. A retrospective comparison of dose ratios between methadone, hydromorphone, and morphine. Cancer. 1996;78(4):852-7.
Bruera, E., Pereira, J., Watanabe, S., Belzile, M., Kuehn, N., & Hanson, J. (1996). Opioid rotation in patients with cancer pain. A retrospective comparison of dose ratios between methadone, hydromorphone, and morphine. Cancer, 78(4), 852-7.
Bruera E, et al. Opioid Rotation in Patients With Cancer Pain. a Retrospective Comparison of Dose Ratios Between Methadone, Hydromorphone, and Morphine. Cancer. 1996 Aug 15;78(4):852-7. PubMed PMID: 8756381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Opioid rotation in patients with cancer pain. A retrospective comparison of dose ratios between methadone, hydromorphone, and morphine. AU - Bruera,E, AU - Pereira,J, AU - Watanabe,S, AU - Belzile,M, AU - Kuehn,N, AU - Hanson,J, PY - 1996/8/15/pubmed PY - 2000/6/20/medline PY - 1996/8/15/entrez SP - 852 EP - 7 JF - Cancer JO - Cancer VL - 78 IS - 4 N2 - BACKGROUND: When a change of opioid is considered, equianalgesic dose tables are used. These tables generally propose a dose ratio of 5:1 between morphine and hydromorphone. In the case of a change from subcutaneous hydromorphone to methadone, dose ratios ranging from 1:6 to 1:10 are proposed. The purpose of this study was to review the analgesic dose ratios for methadone compared with hydromorphone. METHODS: In a retrospective study, 48 cases of medication changes from morphine to hydromorphone, and 65 changes between hydromorphone and methadone were identified. the reason for the change, the analgesic dose, and pain intensity were obtained. RESULTS: The dose ratios between morphine and hydromorphone and vice versa were found to be 5.33 and 0.28, respectively (similar to expected results). However, the hydromorphone/methadone ratio was found to be 1.14:1 (5 to 10 times higher than expected). Although the dose ratios of hydromorphone/morphine and vice versa did not change according to a previous opioid dose, the hydromorphone/methadone ratio correlated with total opioid dose (correlation coefficient = 0.41 P < 0.001) and was 1.6 (range, 0.3-14.4) in patients receiving more than 330 mg of hydromorphone per day prior to the change, versus 0.95 (range, 0.2-12.3) in patients receiving ae330 mg of hydromorphone per day (P = 0.023). CONCLUSIONS: These results suggest that only partial tolerance develops between methadone and hydromorphone. Methadone is much more potent than previously described and any change should start at a lower equivalent dose. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/8756381/Opioid_rotation_in_patients_with_cancer_pain__A_retrospective_comparison_of_dose_ratios_between_methadone_hydromorphone_and_morphine_ L2 - https://medlineplus.gov/pain.html DB - PRIME DP - Unbound Medicine ER -