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Effect of USP apparatus 1 and 2 at different rotational speeds on dissolution of niacin formulations.
J AOAC Int. 1996 Jul-Aug; 79(4):1005-8.JA

Abstract

Forty-four niacin formulations were examined by the United States Pharmacopeia dissolution test, consisting of 0.1N HCl with apparatus 1 and 2. Each formulation was tested with apparatus 1 (basket) at 100 rpm and apparatus 2 (paddle) at 50 and 100 rpm. Dissolution results varied widely among manufacturers.

Authors+Show Affiliations

Kirchhoefer RD
U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Division of Drug Analysis, St. Louis, MO 63101, USA.
Hamilton JF
No affiliation info available

MeSH

CapsulesDelayed-Action PreparationsHydrochloric AcidNiacinPharmacopoeias as TopicProduct Surveillance, PostmarketingSoftwareSolubilitySpectrophotometry, UltravioletUnited States

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8757459

Citation

Kirchhoefer, R D., and J F. Hamilton. "Effect of USP Apparatus 1 and 2 at Different Rotational Speeds On Dissolution of Niacin Formulations." Journal of AOAC International, vol. 79, no. 4, 1996, pp. 1005-8.
Kirchhoefer RD, Hamilton JF. Effect of USP apparatus 1 and 2 at different rotational speeds on dissolution of niacin formulations. J AOAC Int. 1996;79(4):1005-8.
Kirchhoefer, R. D., & Hamilton, J. F. (1996). Effect of USP apparatus 1 and 2 at different rotational speeds on dissolution of niacin formulations. Journal of AOAC International, 79(4), 1005-8.
Kirchhoefer RD, Hamilton JF. Effect of USP Apparatus 1 and 2 at Different Rotational Speeds On Dissolution of Niacin Formulations. J AOAC Int. 1996 Jul-Aug;79(4):1005-8. PubMed PMID: 8757459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of USP apparatus 1 and 2 at different rotational speeds on dissolution of niacin formulations. AU - Kirchhoefer,R D, AU - Hamilton,J F, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez SP - 1005 EP - 8 JF - Journal of AOAC International JO - J AOAC Int VL - 79 IS - 4 N2 - Forty-four niacin formulations were examined by the United States Pharmacopeia dissolution test, consisting of 0.1N HCl with apparatus 1 and 2. Each formulation was tested with apparatus 1 (basket) at 100 rpm and apparatus 2 (paddle) at 50 and 100 rpm. Dissolution results varied widely among manufacturers. SN - 1060-3271 UR - https://www.unboundmedicine.com/medline/citation/8757459/Effect_of_USP_apparatus_1_and_2_at_different_rotational_speeds_on_dissolution_of_niacin_formulations_ DB - PRIME DP - Unbound Medicine ER -