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Ankylosing spondylitis and heterogeneity of HLA-B27 in Chinese.
Chin Med J (Engl). 1996 Apr; 109(4):313-6.CM

Abstract

OBJECTIVE

To examine the relationship between ankylosing spondylitis and heterogeneity of HLA-B27 in Chinese.

PATIENTS AND METHODS

We subtyped HLA-B27 in 76 patients with ankylosing spondylitis and 1 200 healthy Chinese of Han nationality. Polymerase chain reaction was designed to amplify specific regions of class I (exon 2 and 3). Amplified sequences were tested with eight sequence-specific oligonucleotides to distinguish all HLA-B27 subtypes.

RESULTS

The HLA-B27 was closely related to ankylosing spondylitis and at least four subtypes presented in Chinese patients. B2704 was the most common subtype, occurring in 54.8% and 50.85% respectively in HLA-B27 positive ankylosing spondylitis patients and healthy controls. The main HLA-B27 subtypes in the HLA-B27 positive patients distributed in similar proportion to those of HLA-B27 positive healthy controls (P < 0.1).

CONCLUSIONS

The prevalences of various subtypes of HLA-B27 vary in different races. HLA-B2704 is the main subtype in Chinese Han nationality. The HLA-B27 specific residues that are shared by the subtypes might be involved in the pathogenesis of ankylosing spondylitis.

Authors+Show Affiliations

Lin J
Arthritis Clinic and Research Center, People's Hospital, Beijing Medical University.
Lü H
No affiliation info available
Feng C
No affiliation info available

MeSH

AdolescentAdultAgedAsian Continental Ancestry GroupBase SequenceChinaFemaleGenetic HeterogeneityHLA-B27 AntigenHumansMaleMiddle AgedMolecular Sequence DataSpondylitis, Ankylosing

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8758295

Citation

Lin, J, et al. "Ankylosing Spondylitis and Heterogeneity of HLA-B27 in Chinese." Chinese Medical Journal, vol. 109, no. 4, 1996, pp. 313-6.
Lin J, Lü H, Feng C. Ankylosing spondylitis and heterogeneity of HLA-B27 in Chinese. Chin Med J (Engl). 1996;109(4):313-6.
Lin, J., Lü, H., & Feng, C. (1996). Ankylosing spondylitis and heterogeneity of HLA-B27 in Chinese. Chinese Medical Journal, 109(4), 313-6.
Lin J, Lü H, Feng C. Ankylosing Spondylitis and Heterogeneity of HLA-B27 in Chinese. Chin Med J (Engl). 1996;109(4):313-6. PubMed PMID: 8758295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ankylosing spondylitis and heterogeneity of HLA-B27 in Chinese. AU - Lin,J, AU - Lü,H, AU - Feng,C, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 313 EP - 6 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 109 IS - 4 N2 - OBJECTIVE: To examine the relationship between ankylosing spondylitis and heterogeneity of HLA-B27 in Chinese. PATIENTS AND METHODS: We subtyped HLA-B27 in 76 patients with ankylosing spondylitis and 1 200 healthy Chinese of Han nationality. Polymerase chain reaction was designed to amplify specific regions of class I (exon 2 and 3). Amplified sequences were tested with eight sequence-specific oligonucleotides to distinguish all HLA-B27 subtypes. RESULTS: The HLA-B27 was closely related to ankylosing spondylitis and at least four subtypes presented in Chinese patients. B2704 was the most common subtype, occurring in 54.8% and 50.85% respectively in HLA-B27 positive ankylosing spondylitis patients and healthy controls. The main HLA-B27 subtypes in the HLA-B27 positive patients distributed in similar proportion to those of HLA-B27 positive healthy controls (P < 0.1). CONCLUSIONS: The prevalences of various subtypes of HLA-B27 vary in different races. HLA-B2704 is the main subtype in Chinese Han nationality. The HLA-B27 specific residues that are shared by the subtypes might be involved in the pathogenesis of ankylosing spondylitis. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/8758295/Ankylosing_spondylitis_and_heterogeneity_of_HLA_B27_in_Chinese_ L2 - http://www.diseaseinfosearch.org/result/482 DB - PRIME DP - Unbound Medicine ER -