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[Clarithromycin versus amoxicillin-clavulanic acid in the treatment of acute maxillary sinusitis in adults].
Pathol Biol (Paris). 1996 Apr; 44(4):293-7.PB

Abstract

The efficacy and safety of clarithromycin and amoxicillin-clavulanate in the treatment of acute maxillary sinusitis was compared in an open multicenter outpatient study. Two hundred and eighty patients were randomly assigned to receive either clarithromycin 500 mg 12-hourly or amoxicillin-clavulanate 500 mg 8-hourly orally for 8 days. Clinical and radiologic signs and symptoms, and sinus culture were not significantly different in the two treatment groups. A clinical and radiological success or improvement was achieved after the end of treatment in 115/134 (85.8%) patients treated with clarithromycin and in 110/129 (85.3%) patients treated with amoxicillin-clavulanate. Adverse events were reported for 14.8% and 12.2% of patients for clarithromycin and amoxicillin-clavulanate, respectively. In this study clarithromycin was as effective and well tolerated as amoxicillin-clavulanate acid in the treatment of acute maxillary sinusitis.

Authors+Show Affiliations

Service d'ORL, Hôpital Bichat-Claude Bernard, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

fre

PubMed ID

8763594

Citation

Géhanno, P, et al. "[Clarithromycin Versus Amoxicillin-clavulanic Acid in the Treatment of Acute Maxillary Sinusitis in Adults]." Pathologie-biologie, vol. 44, no. 4, 1996, pp. 293-7.
Géhanno P, Barry B, Chauvin JP, et al. [Clarithromycin versus amoxicillin-clavulanic acid in the treatment of acute maxillary sinusitis in adults]. Pathol Biol (Paris). 1996;44(4):293-7.
Géhanno, P., Barry, B., Chauvin, J. P., & Hazebroucq, J. (1996). [Clarithromycin versus amoxicillin-clavulanic acid in the treatment of acute maxillary sinusitis in adults]. Pathologie-biologie, 44(4), 293-7.
Géhanno P, et al. [Clarithromycin Versus Amoxicillin-clavulanic Acid in the Treatment of Acute Maxillary Sinusitis in Adults]. Pathol Biol (Paris). 1996;44(4):293-7. PubMed PMID: 8763594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clarithromycin versus amoxicillin-clavulanic acid in the treatment of acute maxillary sinusitis in adults]. AU - Géhanno,P, AU - Barry,B, AU - Chauvin,J P, AU - Hazebroucq,J, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 293 EP - 7 JF - Pathologie-biologie JO - Pathol Biol (Paris) VL - 44 IS - 4 N2 - The efficacy and safety of clarithromycin and amoxicillin-clavulanate in the treatment of acute maxillary sinusitis was compared in an open multicenter outpatient study. Two hundred and eighty patients were randomly assigned to receive either clarithromycin 500 mg 12-hourly or amoxicillin-clavulanate 500 mg 8-hourly orally for 8 days. Clinical and radiologic signs and symptoms, and sinus culture were not significantly different in the two treatment groups. A clinical and radiological success or improvement was achieved after the end of treatment in 115/134 (85.8%) patients treated with clarithromycin and in 110/129 (85.3%) patients treated with amoxicillin-clavulanate. Adverse events were reported for 14.8% and 12.2% of patients for clarithromycin and amoxicillin-clavulanate, respectively. In this study clarithromycin was as effective and well tolerated as amoxicillin-clavulanate acid in the treatment of acute maxillary sinusitis. SN - 0369-8114 UR - https://www.unboundmedicine.com/medline/citation/8763594/[Clarithromycin_versus_amoxicillin_clavulanic_acid_in_the_treatment_of_acute_maxillary_sinusitis_in_adults]_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -