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[Oral testing for sulfite asthma].
Pneumologie 1996; 50(6):394-8P

Abstract

AIM OF THE STUDY

Patients with asthma may develop bronchoconstriction after ingestion of sulfites. We studied the sensitivity and specificity of an oral provocation challenge with metabisulfite to detect a sulfite-sensitive asthma.

METHODS

We performed an oral dose-response metabisulfite challenge in 44 patients with a history of sulfite-sensitive asthma, 27 patients with asthma but without a history of sulfite sensitivity, and 8 control subjects without asthma. Metabisulfite was administered in capsules in a single-blind manner. Airway response was assessed by FEV decline, measured 30' after each dose.

RESULTS

Thirty-nine percent of patients with a history of sulfite-sensitive asthma demonstrated a significant bronchoconstriction after ingestion of metabisulfite, whereas patients without an appropriate history and control subjects did not respond to the challenge.

CONCLUSIONS

The oral metabisulfite challenge exhibits a high specificity (100%) but low sensitivity of about 40%. Nonetheless, taking into account the uncertainties in the patients' history of sulfite-sensitive asthma, the oral metabisulfite challenge as performed by us is a useful method for the diagnosis of sulfite sensitive asthma.

Authors+Show Affiliations

Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie, Grosshansdorf.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

8766371

Citation

Hein, H, et al. "[Oral Testing for Sulfite Asthma]." Pneumologie (Stuttgart, Germany), vol. 50, no. 6, 1996, pp. 394-8.
Hein H, Kirsten D, Jörres RA, et al. [Oral testing for sulfite asthma]. Pneumologie. 1996;50(6):394-8.
Hein, H., Kirsten, D., Jörres, R. A., & Magnussen, H. (1996). [Oral testing for sulfite asthma]. Pneumologie (Stuttgart, Germany), 50(6), pp. 394-8.
Hein H, et al. [Oral Testing for Sulfite Asthma]. Pneumologie. 1996;50(6):394-8. PubMed PMID: 8766371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Oral testing for sulfite asthma]. AU - Hein,H, AU - Kirsten,D, AU - Jörres,R A, AU - Magnussen,H, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 394 EP - 8 JF - Pneumologie (Stuttgart, Germany) JO - Pneumologie VL - 50 IS - 6 N2 - AIM OF THE STUDY: Patients with asthma may develop bronchoconstriction after ingestion of sulfites. We studied the sensitivity and specificity of an oral provocation challenge with metabisulfite to detect a sulfite-sensitive asthma. METHODS: We performed an oral dose-response metabisulfite challenge in 44 patients with a history of sulfite-sensitive asthma, 27 patients with asthma but without a history of sulfite sensitivity, and 8 control subjects without asthma. Metabisulfite was administered in capsules in a single-blind manner. Airway response was assessed by FEV decline, measured 30' after each dose. RESULTS: Thirty-nine percent of patients with a history of sulfite-sensitive asthma demonstrated a significant bronchoconstriction after ingestion of metabisulfite, whereas patients without an appropriate history and control subjects did not respond to the challenge. CONCLUSIONS: The oral metabisulfite challenge exhibits a high specificity (100%) but low sensitivity of about 40%. Nonetheless, taking into account the uncertainties in the patients' history of sulfite-sensitive asthma, the oral metabisulfite challenge as performed by us is a useful method for the diagnosis of sulfite sensitive asthma. SN - 0934-8387 UR - https://www.unboundmedicine.com/medline/citation/8766371/[Oral_testing_for_sulfite_asthma]_ L2 - http://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -