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Administration of anti-interleukin-2 receptor alpha antibody in vivo induces localized autoimmune disease.
Eur J Immunol. 1996 Jul; 26(7):1608-12.EJ

Abstract

Neonatal thymectomy (Tx) of mice at day 3 after birth (Tx-3), but not day 7 (Tx-7), induces organ-localized autoimmune diseases such as oophoritis and gastritis. Lesions in Tx-3 mice can be prevented by injection of splenic CD4+ cells from syngeneic normal mice, and this CD4+ population with suppressor activity is activated extrathymically by self antigens. Since it is speculated that these CD4+ T suppressor cells (Ts) express the interleukin-2 receptor (IL-2R) as an activated T cell population, an attempt was made to eliminate these Ts from the developing immune system of Tx-7 mice and normal mice by i.p. injection of anti-IL-2R alpha monoclonal antibodies. Interestingly, organ-localized autoimmune disease with quite similar characteristics to those observed after neonatal Tx developed in not only Tx-7 mice, but also normal mice. The results thus indicate that CD4+ cells expressing IL-2R alpha play an important role, as Ts in the periphery, in maintaining immune tolerance.

Authors+Show Affiliations

Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8766568

Citation

Taguchi, O, and T Takahashi. "Administration of Anti-interleukin-2 Receptor Alpha Antibody in Vivo Induces Localized Autoimmune Disease." European Journal of Immunology, vol. 26, no. 7, 1996, pp. 1608-12.
Taguchi O, Takahashi T. Administration of anti-interleukin-2 receptor alpha antibody in vivo induces localized autoimmune disease. Eur J Immunol. 1996;26(7):1608-12.
Taguchi, O., & Takahashi, T. (1996). Administration of anti-interleukin-2 receptor alpha antibody in vivo induces localized autoimmune disease. European Journal of Immunology, 26(7), 1608-12.
Taguchi O, Takahashi T. Administration of Anti-interleukin-2 Receptor Alpha Antibody in Vivo Induces Localized Autoimmune Disease. Eur J Immunol. 1996;26(7):1608-12. PubMed PMID: 8766568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Administration of anti-interleukin-2 receptor alpha antibody in vivo induces localized autoimmune disease. AU - Taguchi,O, AU - Takahashi,T, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez SP - 1608 EP - 12 JF - European journal of immunology JO - Eur. J. Immunol. VL - 26 IS - 7 N2 - Neonatal thymectomy (Tx) of mice at day 3 after birth (Tx-3), but not day 7 (Tx-7), induces organ-localized autoimmune diseases such as oophoritis and gastritis. Lesions in Tx-3 mice can be prevented by injection of splenic CD4+ cells from syngeneic normal mice, and this CD4+ population with suppressor activity is activated extrathymically by self antigens. Since it is speculated that these CD4+ T suppressor cells (Ts) express the interleukin-2 receptor (IL-2R) as an activated T cell population, an attempt was made to eliminate these Ts from the developing immune system of Tx-7 mice and normal mice by i.p. injection of anti-IL-2R alpha monoclonal antibodies. Interestingly, organ-localized autoimmune disease with quite similar characteristics to those observed after neonatal Tx developed in not only Tx-7 mice, but also normal mice. The results thus indicate that CD4+ cells expressing IL-2R alpha play an important role, as Ts in the periphery, in maintaining immune tolerance. SN - 0014-2980 UR - https://www.unboundmedicine.com/medline/citation/8766568/Administration_of_anti_interleukin_2_receptor_alpha_antibody_in_vivo_induces_localized_autoimmune_disease_ L2 - https://doi.org/10.1002/eji.1830260730 DB - PRIME DP - Unbound Medicine ER -