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Interferon-gamma is required during the initiation of an organ-specific autoimmune disease.
Eur J Immunol 1996; 26(7):1652-5EJ

Abstract

Autoimmune gastritis induced by neonatal thymectomy of mice is a CD4+ T cell-mediated organ-specific autoimmune disease. The characteristic features of autoimmune gastritis, which include a mononuclear infiltrate within the gastric mucosa, loss of parietal and chief cells and circulating autoantibodies to the gastric H+/K+ ATPase, appear 6-10 weeks after thymectomy. Here we have assessed the role of interferon-gamma (IFN-gamma) in the pathogenesis of the gastric lesion. Splenic T cells derived from mice with gastritis produced three- to tenfold more IFN-gamma than T cells from normal animals after stimulation with anti-CD3 antibodies. Treatment of neonatally thymectomized mice at weekly intervals for 6 or 12 weeks with a neutralizing rat monoclonal antibody to mouse IFN-gamma abolished the production of anti-gastric autoantibodies and decreased the incidence of gastric mononuclear infiltrates from the 69% observed in normal rat immunoglobulin (Ig)-injected mice to 16%. Further, in mice treated with only a single dose of anti-IFN-gamma immediately after thymectomy at 3 days after birth, the incidence of autoimmune gastritis was 1/19 compared to 8/19 in normal rat Ig-injected mice. Prevention of autoimmunity by neutralization of IFN-gamma several weeks prior to the detection of a pathological lesion strongly suggests that IFN-gamma plays an essential role in the initiation of the gastric autoimmune response.

Authors+Show Affiliations

Department of Pathology and Immunology, Monash University Medical School, Melbourne, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8766575

Citation

Barrett, S P., et al. "Interferon-gamma Is Required During the Initiation of an Organ-specific Autoimmune Disease." European Journal of Immunology, vol. 26, no. 7, 1996, pp. 1652-5.
Barrett SP, Gleeson PA, de Silva H, et al. Interferon-gamma is required during the initiation of an organ-specific autoimmune disease. Eur J Immunol. 1996;26(7):1652-5.
Barrett, S. P., Gleeson, P. A., de Silva, H., Toh, B. H., & van Driel, I. R. (1996). Interferon-gamma is required during the initiation of an organ-specific autoimmune disease. European Journal of Immunology, 26(7), pp. 1652-5.
Barrett SP, et al. Interferon-gamma Is Required During the Initiation of an Organ-specific Autoimmune Disease. Eur J Immunol. 1996;26(7):1652-5. PubMed PMID: 8766575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interferon-gamma is required during the initiation of an organ-specific autoimmune disease. AU - Barrett,S P, AU - Gleeson,P A, AU - de Silva,H, AU - Toh,B H, AU - van Driel,I R, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez SP - 1652 EP - 5 JF - European journal of immunology JO - Eur. J. Immunol. VL - 26 IS - 7 N2 - Autoimmune gastritis induced by neonatal thymectomy of mice is a CD4+ T cell-mediated organ-specific autoimmune disease. The characteristic features of autoimmune gastritis, which include a mononuclear infiltrate within the gastric mucosa, loss of parietal and chief cells and circulating autoantibodies to the gastric H+/K+ ATPase, appear 6-10 weeks after thymectomy. Here we have assessed the role of interferon-gamma (IFN-gamma) in the pathogenesis of the gastric lesion. Splenic T cells derived from mice with gastritis produced three- to tenfold more IFN-gamma than T cells from normal animals after stimulation with anti-CD3 antibodies. Treatment of neonatally thymectomized mice at weekly intervals for 6 or 12 weeks with a neutralizing rat monoclonal antibody to mouse IFN-gamma abolished the production of anti-gastric autoantibodies and decreased the incidence of gastric mononuclear infiltrates from the 69% observed in normal rat immunoglobulin (Ig)-injected mice to 16%. Further, in mice treated with only a single dose of anti-IFN-gamma immediately after thymectomy at 3 days after birth, the incidence of autoimmune gastritis was 1/19 compared to 8/19 in normal rat Ig-injected mice. Prevention of autoimmunity by neutralization of IFN-gamma several weeks prior to the detection of a pathological lesion strongly suggests that IFN-gamma plays an essential role in the initiation of the gastric autoimmune response. SN - 0014-2980 UR - https://www.unboundmedicine.com/medline/citation/8766575/Interferon_gamma_is_required_during_the_initiation_of_an_organ_specific_autoimmune_disease_ L2 - https://doi.org/10.1002/eji.1830260737 DB - PRIME DP - Unbound Medicine ER -