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[Methodological constraints in evaluating anti-deficit effects].
Encephale. 1996 Jun; 22 Spec No 2:25-7.E

Abstract

Several types of limitations are inherent in the evaluation of changes in negative symptoms during clinical trials. Some of these limitations can be listed as follows: the need to select homogeneous study populations (use of a standardized diagnosis), identification of negative dimensions which feature deficitary forms of schizophrenia (qualitative criteria and threshold scores using negative symptom rating tables), strict control of variables which may induce secondary negative symptoms (treatments, other associated disorders particularly of a depressive type, lack of environmental stimulus), follow-up of stability of negative symptoms and, finally, an adequate time interval for evaluation in order to exclude spontaneous and non-specific fluctuations of symptomatology.

Authors+Show Affiliations

INSERM, CMME, Paris.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

8767038

Citation

Boyer, P, et al. "[Methodological Constraints in Evaluating Anti-deficit Effects]." L'Encephale, vol. 22 Spec No 2, 1996, pp. 25-7.
Boyer P, Lecrubier Y, Rein W. [Methodological constraints in evaluating anti-deficit effects]. Encephale. 1996;22 Spec No 2:25-7.
Boyer, P., Lecrubier, Y., & Rein, W. (1996). [Methodological constraints in evaluating anti-deficit effects]. L'Encephale, 22 Spec No 2, 25-7.
Boyer P, Lecrubier Y, Rein W. [Methodological Constraints in Evaluating Anti-deficit Effects]. Encephale. 1996;22 Spec No 2:25-7. PubMed PMID: 8767038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Methodological constraints in evaluating anti-deficit effects]. AU - Boyer,P, AU - Lecrubier,Y, AU - Rein,W, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 25 EP - 7 JF - L'Encephale JO - Encephale VL - 22 Spec No 2 N2 - Several types of limitations are inherent in the evaluation of changes in negative symptoms during clinical trials. Some of these limitations can be listed as follows: the need to select homogeneous study populations (use of a standardized diagnosis), identification of negative dimensions which feature deficitary forms of schizophrenia (qualitative criteria and threshold scores using negative symptom rating tables), strict control of variables which may induce secondary negative symptoms (treatments, other associated disorders particularly of a depressive type, lack of environmental stimulus), follow-up of stability of negative symptoms and, finally, an adequate time interval for evaluation in order to exclude spontaneous and non-specific fluctuations of symptomatology. SN - 0013-7006 UR - https://www.unboundmedicine.com/medline/citation/8767038/[Methodological_constraints_in_evaluating_anti_deficit_effects]_ L2 - https://medlineplus.gov/depression.html DB - PRIME DP - Unbound Medicine ER -