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Histamine in wine. Bronchoconstriction after a double-blind placebo-controlled red wine provocation test.

Abstract

A 38-year-old woman with a history of seasonal rhinoconjunctivitis reported repeated attacks of wheezing after drinking various alcoholic beverages. Two consecutive histamine provocations using two identical samples of red wine containing 200 micrograms histamine/l and 3,700 micrograms/l, respectively, were performed in a double-blind placebo-controlled fashion to assess a possible histamine-induced bronchoconstriction. Lung function, plasma histamine, skin temperature, pulse rate and symptoms were assessed. In 3 male controls, four consecutive wine tests were performed in a randomised double-blind placebo-controlled fashion. Drinking wine with 3,700 micrograms histamine/l caused coughing and wheezing with a decrease in lung function. Plasma histamine showed an increase at 10 and 20 min and decreased at 30 min both after histamine-rich as well as histamine-poor wine, reaching the peak increase after histamine-rich wine. Controls did not react and plasma histamine levels did not increase. Bronchoconstriction after wine or food rich in histamine seems to be caused by diminished histamine degradation on the basis of reduced activity of diamine oxidase. Histamine in wine may induce bronchoconstriction in patients suffering from histamine intolerance.

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  • Authors+Show Affiliations

    ,

    Dermatologic and Pediatric Allergy Clinic, Wilhelminenspital, Vienna, Austria.

    , , ,

    Source

    MeSH

    Adult
    Asthma
    Bronchial Provocation Tests
    Bronchoconstriction
    Double-Blind Method
    Female
    Histamine
    Humans
    Male
    Rhinitis, Allergic, Seasonal
    Wine

    Pub Type(s)

    Case Reports
    Clinical Trial
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    8768808

    Citation

    Wantke, F, et al. "Histamine in Wine. Bronchoconstriction After a Double-blind Placebo-controlled Red Wine Provocation Test." International Archives of Allergy and Immunology, vol. 110, no. 4, 1996, pp. 397-400.
    Wantke F, Hemmer W, Haglmüller T, et al. Histamine in wine. Bronchoconstriction after a double-blind placebo-controlled red wine provocation test. Int Arch Allergy Immunol. 1996;110(4):397-400.
    Wantke, F., Hemmer, W., Haglmüller, T., Götz, M., & Jarisch, R. (1996). Histamine in wine. Bronchoconstriction after a double-blind placebo-controlled red wine provocation test. International Archives of Allergy and Immunology, 110(4), pp. 397-400.
    Wantke F, et al. Histamine in Wine. Bronchoconstriction After a Double-blind Placebo-controlled Red Wine Provocation Test. Int Arch Allergy Immunol. 1996;110(4):397-400. PubMed PMID: 8768808.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Histamine in wine. Bronchoconstriction after a double-blind placebo-controlled red wine provocation test. AU - Wantke,F, AU - Hemmer,W, AU - Haglmüller,T, AU - Götz,M, AU - Jarisch,R, PY - 1996/8/1/pubmed PY - 1996/8/1/medline PY - 1996/8/1/entrez SP - 397 EP - 400 JF - International archives of allergy and immunology JO - Int. Arch. Allergy Immunol. VL - 110 IS - 4 N2 - A 38-year-old woman with a history of seasonal rhinoconjunctivitis reported repeated attacks of wheezing after drinking various alcoholic beverages. Two consecutive histamine provocations using two identical samples of red wine containing 200 micrograms histamine/l and 3,700 micrograms/l, respectively, were performed in a double-blind placebo-controlled fashion to assess a possible histamine-induced bronchoconstriction. Lung function, plasma histamine, skin temperature, pulse rate and symptoms were assessed. In 3 male controls, four consecutive wine tests were performed in a randomised double-blind placebo-controlled fashion. Drinking wine with 3,700 micrograms histamine/l caused coughing and wheezing with a decrease in lung function. Plasma histamine showed an increase at 10 and 20 min and decreased at 30 min both after histamine-rich as well as histamine-poor wine, reaching the peak increase after histamine-rich wine. Controls did not react and plasma histamine levels did not increase. Bronchoconstriction after wine or food rich in histamine seems to be caused by diminished histamine degradation on the basis of reduced activity of diamine oxidase. Histamine in wine may induce bronchoconstriction in patients suffering from histamine intolerance. SN - 1018-2438 UR - https://www.unboundmedicine.com/medline/citation/8768808/Histamine_in_wine__Bronchoconstriction_after_a_double_blind_placebo_controlled_red_wine_provocation_test_ L2 - https://www.karger.com?DOI=10.1159/000237333 DB - PRIME DP - Unbound Medicine ER -