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Antiviral effect of Sanicula europaea L. leaves extract on influenza virus-infected cells.
Biochem Biophys Res Commun. 1996 Aug 05; 225(1):22-6.BB

Abstract

We have investigated the influence of Sanicula europaea L. extracts on influenza virus growth in MDCK cells. Fractions I, II, and III separated from Sanicula extract with Sephadex column chromatography were found to be non-toxic against MDCK cells. The growth of influenza A/PR/8/34 was completely inhibited by these fractions, while that of influenza B/Lee/40 was not affected. Fractions II and III have been shown not to have a direct virucidal activity on influenza A/PR/8/34. Influenza A/Vic/1/75 produced microscopic plaques in the presence of the extract. In vitro RNA synthesis with viral RNA-dependent RNA polymerase was also inhibited by a water soluble extract of Sanicula. These observations suggest that the Sanicula extract contains an anti-influenza virus substance.

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Publisher Full Text

Authors+Show Affiliations

Turan K
Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Turkey.
Nagata K
No affiliation info available
Kuru A
No affiliation info available

MeSH

AnimalsAntiviral AgentsCell LineChromatography, GelDogsInfluenza A virusKidneyKineticsPlant ExtractsPlant LeavesPlants, MedicinalTime FactorsViral Plaque AssayVirus Replication

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8769089

Citation

Turan, K, et al. "Antiviral Effect of Sanicula Europaea L. Leaves Extract On Influenza Virus-infected Cells." Biochemical and Biophysical Research Communications, vol. 225, no. 1, 1996, pp. 22-6.
Turan K, Nagata K, Kuru A. Antiviral effect of Sanicula europaea L. leaves extract on influenza virus-infected cells. Biochem Biophys Res Commun. 1996;225(1):22-6.
Turan, K., Nagata, K., & Kuru, A. (1996). Antiviral effect of Sanicula europaea L. leaves extract on influenza virus-infected cells. Biochemical and Biophysical Research Communications, 225(1), 22-6.
Turan K, Nagata K, Kuru A. Antiviral Effect of Sanicula Europaea L. Leaves Extract On Influenza Virus-infected Cells. Biochem Biophys Res Commun. 1996 Aug 5;225(1):22-6. PubMed PMID: 8769089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiviral effect of Sanicula europaea L. leaves extract on influenza virus-infected cells. AU - Turan,K, AU - Nagata,K, AU - Kuru,A, PY - 1996/8/5/pubmed PY - 1996/8/5/medline PY - 1996/8/5/entrez SP - 22 EP - 6 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 225 IS - 1 N2 - We have investigated the influence of Sanicula europaea L. extracts on influenza virus growth in MDCK cells. Fractions I, II, and III separated from Sanicula extract with Sephadex column chromatography were found to be non-toxic against MDCK cells. The growth of influenza A/PR/8/34 was completely inhibited by these fractions, while that of influenza B/Lee/40 was not affected. Fractions II and III have been shown not to have a direct virucidal activity on influenza A/PR/8/34. Influenza A/Vic/1/75 produced microscopic plaques in the presence of the extract. In vitro RNA synthesis with viral RNA-dependent RNA polymerase was also inhibited by a water soluble extract of Sanicula. These observations suggest that the Sanicula extract contains an anti-influenza virus substance. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/8769089/Antiviral_effect_of_Sanicula_europaea_L__leaves_extract_on_influenza_virus_infected_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(96)91125-0 DB - PRIME DP - Unbound Medicine ER -