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Environmental and genetic risk factors in Parkinson's disease: a case-control study in southern Italy.
Mov Disord. 1996 Jan; 11(1):17-23.MD

Abstract

To clarify the role of heredity and of some environment risk factors in the etiology of idiopathic Parkinson's disease, we performed a case-control study in two regions of southern Italy, Campania and Molise. We selected two controls for each parkinsonian patient, the patient's spouse and a sex- and age-matched neurological control. One hundred sixteen consecutive outpatients with Parkinson's disease (77 men, 39 women; mean age +/- SD = 62.5 +/- 9.9) and the same number of spouses and neurological controls were interviewed about five environmental risk factors (cigarette smoking, well-water drinking, head trauma with loss of consciousness, strict diets, general anesthesia) and two genetic risk factors (family history of Parkinson's disease or of essential tremor). Well-water drinking and family history of Parkinson's disease or essential tremor showed a positive association with Parkinson's disease; smoking showed a negative association. The most relevant risk factor was history of familial Parkinson's disease (odds ratio = 14.6; 95% confidence interval = 7.2 - 29.6); 33% of our patients had at least one affected relative. We also showed a unilateral distribution of ancestral secondary cases on the paternal or on the maternal side, which suggests a dominant inheritance. Clinical and epidemiologic features of cases with familial Parkinson's disease showed no peculiarity. The study suggests a strong role of the genetic factors in the etiology of Parkinson's disease.

Authors+Show Affiliations

Department of Neurology, Federico II University, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8771062

Citation

De Michele, G, et al. "Environmental and Genetic Risk Factors in Parkinson's Disease: a Case-control Study in Southern Italy." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 11, no. 1, 1996, pp. 17-23.
De Michele G, Filla A, Volpe G, et al. Environmental and genetic risk factors in Parkinson's disease: a case-control study in southern Italy. Mov Disord. 1996;11(1):17-23.
De Michele, G., Filla, A., Volpe, G., De Marco, V., Gogliettino, A., Ambrosio, G., Marconi, R., Castellano, A. E., & Campanella, G. (1996). Environmental and genetic risk factors in Parkinson's disease: a case-control study in southern Italy. Movement Disorders : Official Journal of the Movement Disorder Society, 11(1), 17-23.
De Michele G, et al. Environmental and Genetic Risk Factors in Parkinson's Disease: a Case-control Study in Southern Italy. Mov Disord. 1996;11(1):17-23. PubMed PMID: 8771062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Environmental and genetic risk factors in Parkinson's disease: a case-control study in southern Italy. AU - De Michele,G, AU - Filla,A, AU - Volpe,G, AU - De Marco,V, AU - Gogliettino,A, AU - Ambrosio,G, AU - Marconi,R, AU - Castellano,A E, AU - Campanella,G, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 17 EP - 23 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 11 IS - 1 N2 - To clarify the role of heredity and of some environment risk factors in the etiology of idiopathic Parkinson's disease, we performed a case-control study in two regions of southern Italy, Campania and Molise. We selected two controls for each parkinsonian patient, the patient's spouse and a sex- and age-matched neurological control. One hundred sixteen consecutive outpatients with Parkinson's disease (77 men, 39 women; mean age +/- SD = 62.5 +/- 9.9) and the same number of spouses and neurological controls were interviewed about five environmental risk factors (cigarette smoking, well-water drinking, head trauma with loss of consciousness, strict diets, general anesthesia) and two genetic risk factors (family history of Parkinson's disease or of essential tremor). Well-water drinking and family history of Parkinson's disease or essential tremor showed a positive association with Parkinson's disease; smoking showed a negative association. The most relevant risk factor was history of familial Parkinson's disease (odds ratio = 14.6; 95% confidence interval = 7.2 - 29.6); 33% of our patients had at least one affected relative. We also showed a unilateral distribution of ancestral secondary cases on the paternal or on the maternal side, which suggests a dominant inheritance. Clinical and epidemiologic features of cases with familial Parkinson's disease showed no peculiarity. The study suggests a strong role of the genetic factors in the etiology of Parkinson's disease. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/8771062/Environmental_and_genetic_risk_factors_in_Parkinson's_disease:_a_case_control_study_in_southern_Italy_ L2 - https://doi.org/10.1002/mds.870110105 DB - PRIME DP - Unbound Medicine ER -