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Induction of bradykinin B1 hypotensive receptors in rats by lipopolysaccharide.
Can J Physiol Pharmacol. 1996 Mar; 74(3):337-40.CJ

Abstract

Bolus injections of bradykinin (BK, 0.25-1.0 nmol.kg-1 intraarterially (i.a.)) in anesthetized rats produced a dose-dependent hypotensive response, while desArg9-BK (0.25-1.0 nmol.kg-1 i.a.), Lys-desArg9-BK (0.25-1.0 nmol.kg-1 i.a.), and Sar[D-Phe8]desArg9-BK (0.5-1.0 nmol.kg-1 i.a.) were inactive. At 12-24 h after the pretreatment with lipopolysaccharide (10-100 micrograms.kg-1 i.v.), BK produced a greater decrease in blood pressure than in nontreated rats and Sar[D-Phe8]desArg9-BK (0.5-1.0 nmol.kg-1 i.a.) decreased blood pressure by 13.0 +/- 1.0 and 22.2 +/- 2.31 mmHg (1 mmHg = 133.3 Pa), whereas both desArg9-BK and desArg10-kallidin were inactive. The hypotensive effect of BK (0.25-1.0 nmol.kg-1 i.a.) was significantly reduced by HOE-140 (1.0 nmol.kg-1 i.a.) given 5 min before and that of Sar[D-Phe8]desArg9-BK was reduced by [Leu8]desArg9-BK (1.0 nmol.kg-1 i.a.) given 3 min before the agonists. These results indicate that in rats lipopolysaccharide induces B1 receptors in 18 to 24 h. B1 agonists protected from degradation are needed to demonstrate the presence of B1-receptor-mediated hypotension in the rat.

Authors+Show Affiliations

Departamento de Ciĕncias Fisiológicas, Universidade Federal de Santa Catarina, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8773415

Citation

Nicolau, M, et al. "Induction of Bradykinin B1 Hypotensive Receptors in Rats By Lipopolysaccharide." Canadian Journal of Physiology and Pharmacology, vol. 74, no. 3, 1996, pp. 337-40.
Nicolau M, Feltrin MR, Regoli D. Induction of bradykinin B1 hypotensive receptors in rats by lipopolysaccharide. Can J Physiol Pharmacol. 1996;74(3):337-40.
Nicolau, M., Feltrin, M. R., & Regoli, D. (1996). Induction of bradykinin B1 hypotensive receptors in rats by lipopolysaccharide. Canadian Journal of Physiology and Pharmacology, 74(3), 337-40.
Nicolau M, Feltrin MR, Regoli D. Induction of Bradykinin B1 Hypotensive Receptors in Rats By Lipopolysaccharide. Can J Physiol Pharmacol. 1996;74(3):337-40. PubMed PMID: 8773415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induction of bradykinin B1 hypotensive receptors in rats by lipopolysaccharide. AU - Nicolau,M, AU - Feltrin,M R, AU - Regoli,D, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 337 EP - 40 JF - Canadian journal of physiology and pharmacology JO - Can J Physiol Pharmacol VL - 74 IS - 3 N2 - Bolus injections of bradykinin (BK, 0.25-1.0 nmol.kg-1 intraarterially (i.a.)) in anesthetized rats produced a dose-dependent hypotensive response, while desArg9-BK (0.25-1.0 nmol.kg-1 i.a.), Lys-desArg9-BK (0.25-1.0 nmol.kg-1 i.a.), and Sar[D-Phe8]desArg9-BK (0.5-1.0 nmol.kg-1 i.a.) were inactive. At 12-24 h after the pretreatment with lipopolysaccharide (10-100 micrograms.kg-1 i.v.), BK produced a greater decrease in blood pressure than in nontreated rats and Sar[D-Phe8]desArg9-BK (0.5-1.0 nmol.kg-1 i.a.) decreased blood pressure by 13.0 +/- 1.0 and 22.2 +/- 2.31 mmHg (1 mmHg = 133.3 Pa), whereas both desArg9-BK and desArg10-kallidin were inactive. The hypotensive effect of BK (0.25-1.0 nmol.kg-1 i.a.) was significantly reduced by HOE-140 (1.0 nmol.kg-1 i.a.) given 5 min before and that of Sar[D-Phe8]desArg9-BK was reduced by [Leu8]desArg9-BK (1.0 nmol.kg-1 i.a.) given 3 min before the agonists. These results indicate that in rats lipopolysaccharide induces B1 receptors in 18 to 24 h. B1 agonists protected from degradation are needed to demonstrate the presence of B1-receptor-mediated hypotension in the rat. SN - 0008-4212 UR - https://www.unboundmedicine.com/medline/citation/8773415/Induction_of_bradykinin_B1_hypotensive_receptors_in_rats_by_lipopolysaccharide_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8773415.ui DB - PRIME DP - Unbound Medicine ER -