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Lack of association between early exposure to cow's milk protein and beta-cell autoimmunity. Diabetes Autoimmunity Study in the Young (DAISY)
JAMA 1996; 276(8):609-14JAMA

Abstract

OBJECTIVE

To examine whether infant dietary exposure to cow's milk is associated with beta-cell autoimmunity (BCA), an early predictor of insulin-dependent diabetes mellitus (IDDM).

SETTING

Denver, Colo.

DESIGN

Cross-sectional with retrospective analysis.

PARTICIPANTS

Between January 1994 and December 1995, 253 children from 171 families of persons with IDDM were screened for BCA. All children were between the ages of 9 months and 7 years.

MAIN OUTCOME MEASURES

BCA was defined as elevated levels of insulin autoantibody, glutamic acid decarboxylase autoantibody, or insulinoma-associated islet tyrosine phosphatases autoantibody (IA-2) above the 99th percentile of 198 normal subjects.

RESULTS

Eighteen cases of BCA were detected; 153 unrelated autoantibody-negative children were selected from the cohort as controls. There were no differences in the proportion of cases and controls who were exposed to cow's milk or foods containing cow's milk or to cereal, fruit and vegetable, or meat protein by 3 months or by 6 months of age. Children with BCA were breast-fed for a slightly longer duration than controls (median duration 10 vs 8 months, P=.07).

CONCLUSIONS

These data suggest that early exposure to cow's milk or other dietary protein is not associated with BCA. This calls into question the importance of cow's milk avoidance as a preventive measure for IDDM.

Authors+Show Affiliations

Department of Preventive Medicine and Biometrics, University of Colorado School of Medicine, Denver 80262, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8773632

Citation

Norris, J M., et al. "Lack of Association Between Early Exposure to Cow's Milk Protein and Beta-cell Autoimmunity. Diabetes Autoimmunity Study in the Young (DAISY)." JAMA, vol. 276, no. 8, 1996, pp. 609-14.
Norris JM, Beaty B, Klingensmith G, et al. Lack of association between early exposure to cow's milk protein and beta-cell autoimmunity. Diabetes Autoimmunity Study in the Young (DAISY). JAMA. 1996;276(8):609-14.
Norris, J. M., Beaty, B., Klingensmith, G., Yu Liping, ., Hoffman, M., Chase, H. P., ... Rewers, M. (1996). Lack of association between early exposure to cow's milk protein and beta-cell autoimmunity. Diabetes Autoimmunity Study in the Young (DAISY). JAMA, 276(8), pp. 609-14.
Norris JM, et al. Lack of Association Between Early Exposure to Cow's Milk Protein and Beta-cell Autoimmunity. Diabetes Autoimmunity Study in the Young (DAISY). JAMA. 1996 Aug 28;276(8):609-14. PubMed PMID: 8773632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of association between early exposure to cow's milk protein and beta-cell autoimmunity. Diabetes Autoimmunity Study in the Young (DAISY) AU - Norris,J M, AU - Beaty,B, AU - Klingensmith,G, AU - Yu Liping,, AU - Hoffman,M, AU - Chase,H P, AU - Erlich,H A, AU - Hamman,R F, AU - Eisenbarth,G S, AU - Rewers,M, PY - 1996/8/28/pubmed PY - 1996/8/28/medline PY - 1996/8/28/entrez SP - 609 EP - 14 JF - JAMA JO - JAMA VL - 276 IS - 8 N2 - OBJECTIVE: To examine whether infant dietary exposure to cow's milk is associated with beta-cell autoimmunity (BCA), an early predictor of insulin-dependent diabetes mellitus (IDDM). SETTING: Denver, Colo. DESIGN: Cross-sectional with retrospective analysis. PARTICIPANTS: Between January 1994 and December 1995, 253 children from 171 families of persons with IDDM were screened for BCA. All children were between the ages of 9 months and 7 years. MAIN OUTCOME MEASURES: BCA was defined as elevated levels of insulin autoantibody, glutamic acid decarboxylase autoantibody, or insulinoma-associated islet tyrosine phosphatases autoantibody (IA-2) above the 99th percentile of 198 normal subjects. RESULTS: Eighteen cases of BCA were detected; 153 unrelated autoantibody-negative children were selected from the cohort as controls. There were no differences in the proportion of cases and controls who were exposed to cow's milk or foods containing cow's milk or to cereal, fruit and vegetable, or meat protein by 3 months or by 6 months of age. Children with BCA were breast-fed for a slightly longer duration than controls (median duration 10 vs 8 months, P=.07). CONCLUSIONS: These data suggest that early exposure to cow's milk or other dietary protein is not associated with BCA. This calls into question the importance of cow's milk avoidance as a preventive measure for IDDM. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/8773632/Lack_of_association_between_early_exposure_to_cow's_milk_protein_and_beta_cell_autoimmunity__Diabetes_Autoimmunity_Study_in_the_Young__DAISY_ L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/276/pg/609 DB - PRIME DP - Unbound Medicine ER -