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Zimmermann-Laband syndrome in a patient with severe mental retardation.
Genet Couns. 1995; 6(4):321-7.GC

Abstract

Zimmermann-Laband syndrome in a patient with severe mental retardation: The Zimmermann-Laband syndrome (ZLS) is a rare autosomal dominant disorder characterized by gingival hyperplasia or fibromatosis, various skeletal anomalies including dysplasia of the distal phalanges of thumbs and halluces, vertebral defects, and hepatosplenomegaly. Thus far, 23 cases, including 11 patients from 2 families, have been reported. Most cases of ZLS have a normal intelligence although some cases are mildly retarded. Differential diagnosis includes other causes of gingival hyperplasia. We report on a patient with ZLS and severe mental retardation and review the literature. We conclude that severe mental retardation is a feature of the syndrome.

Authors+Show Affiliations

Van Buggenhout GJ
Department of Human Genetics, University Hospital Nijmegen, Netherlands.
Brunner HG
No affiliation info available
Trommelen JC
No affiliation info available
Hamel BC
No affiliation info available

MeSH

Abnormalities, MultipleChromosome AberrationsChromosome DisordersDiagnosis, DifferentialFacial BonesFibromatosis, GingivalFingersGenes, DominantGingival HyperplasiaHumansIntellectual DisabilityMaleMiddle AgedSkullSyndrome

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8775419

Citation

Van Buggenhout, G J., et al. "Zimmermann-Laband Syndrome in a Patient With Severe Mental Retardation." Genetic Counseling (Geneva, Switzerland), vol. 6, no. 4, 1995, pp. 321-7.
Van Buggenhout GJ, Brunner HG, Trommelen JC, et al. Zimmermann-Laband syndrome in a patient with severe mental retardation. Genet Couns. 1995;6(4):321-7.
Van Buggenhout, G. J., Brunner, H. G., Trommelen, J. C., & Hamel, B. C. (1995). Zimmermann-Laband syndrome in a patient with severe mental retardation. Genetic Counseling (Geneva, Switzerland), 6(4), 321-7.
Van Buggenhout GJ, et al. Zimmermann-Laband Syndrome in a Patient With Severe Mental Retardation. Genet Couns. 1995;6(4):321-7. PubMed PMID: 8775419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zimmermann-Laband syndrome in a patient with severe mental retardation. AU - Van Buggenhout,G J, AU - Brunner,H G, AU - Trommelen,J C, AU - Hamel,B C, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 321 EP - 7 JF - Genetic counseling (Geneva, Switzerland) JO - Genet Couns VL - 6 IS - 4 N2 - Zimmermann-Laband syndrome in a patient with severe mental retardation: The Zimmermann-Laband syndrome (ZLS) is a rare autosomal dominant disorder characterized by gingival hyperplasia or fibromatosis, various skeletal anomalies including dysplasia of the distal phalanges of thumbs and halluces, vertebral defects, and hepatosplenomegaly. Thus far, 23 cases, including 11 patients from 2 families, have been reported. Most cases of ZLS have a normal intelligence although some cases are mildly retarded. Differential diagnosis includes other causes of gingival hyperplasia. We report on a patient with ZLS and severe mental retardation and review the literature. We conclude that severe mental retardation is a feature of the syndrome. SN - 1015-8146 UR - https://www.unboundmedicine.com/medline/citation/8775419/Zimmermann_Laband_syndrome_in_a_patient_with_severe_mental_retardation_ L2 - http://www.diseaseinfosearch.org/result/4607 DB - PRIME DP - Unbound Medicine ER -