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Simultaneous determination of gastric emptying and intestinal absorption during cycle exercise in humans.
Int J Sports Med. 1996 Jan; 17(1):48-55.IJ

Abstract

Because fluid absorption values derived from intestinal perfusion may not represent intestinal absorption of the same solution following its oral ingestion, the present study measured intestinal absorption following oral ingestion of a beverage. To do so required the simultaneous determination of gastric emptying. Seven males positioned a nasogastric tube in the gastric antrum and a multilumen tube in the duodenum under fluoroscopic guidance. Gastric emptying (GE) and intestinal water flux (WF) were measured during 85 min of cycle exercise at 60.6 +/- 3.7% VO2max (x +/- SE) in a 22 degrees C environment. Subjects ingested a total of 23 ml.kg-1 body weight (2005 +/- 187 ml) of a 6% isotonic carbohydrate-electrolyte solution by drinking 396 +/- 34 ml 5 min prior to exercise followed by 198 +/- 17 ml every 10 min during exercise. Mean stomach volume (312 +/- 80 ml) and GE (19.7 +/- 2.0 ml.min-1) did not change significantly after the initial 35 min equilibration period. Mean WF during oral ingestion of the solution (19.5 +/- 2.6 ml.cm-1.h-1) did not differ significantly from mean WF (16.4 +/- 1.9 ml.cm-1.h-1) during perfusion of the same solution directly into the duodenum at a rate equal to each subject's GE rate. Total solute flux (mmol.cm-1.h-1) was not different between drinking (4.1 +/- 1.3) and infusion (3.8 +/- 1.0) trials, nor were the changes in plasma volume. Urine production immediately following the exercise bout was unchanged between drinking (89.1 +/- 27.5 ml) and perfusion (88.5 +/- 24.2) experiments. These data indicate that: 1) relatively constant stomach volumes can be maintained over a prolonged period of time and can produce relatively constant GE rates, and 2) intestinal absorption of an isotonic carbohydrate-electrolyte beverage can be accurately determined by a modified segmental perfusion technique employing ingestion rather than intestinal perfusion.

Authors+Show Affiliations

Department of Physiology, University of Iowa, Iowa City, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8775576

Citation

Lambert, G P., et al. "Simultaneous Determination of Gastric Emptying and Intestinal Absorption During Cycle Exercise in Humans." International Journal of Sports Medicine, vol. 17, no. 1, 1996, pp. 48-55.
Lambert GP, Chang RT, Joensen D, et al. Simultaneous determination of gastric emptying and intestinal absorption during cycle exercise in humans. Int J Sports Med. 1996;17(1):48-55.
Lambert, G. P., Chang, R. T., Joensen, D., Shi, X., Summers, R. W., Schedl, H. P., & Gisolfi, C. V. (1996). Simultaneous determination of gastric emptying and intestinal absorption during cycle exercise in humans. International Journal of Sports Medicine, 17(1), 48-55.
Lambert GP, et al. Simultaneous Determination of Gastric Emptying and Intestinal Absorption During Cycle Exercise in Humans. Int J Sports Med. 1996;17(1):48-55. PubMed PMID: 8775576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous determination of gastric emptying and intestinal absorption during cycle exercise in humans. AU - Lambert,G P, AU - Chang,R T, AU - Joensen,D, AU - Shi,X, AU - Summers,R W, AU - Schedl,H P, AU - Gisolfi,C V, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 48 EP - 55 JF - International journal of sports medicine JO - Int J Sports Med VL - 17 IS - 1 N2 - Because fluid absorption values derived from intestinal perfusion may not represent intestinal absorption of the same solution following its oral ingestion, the present study measured intestinal absorption following oral ingestion of a beverage. To do so required the simultaneous determination of gastric emptying. Seven males positioned a nasogastric tube in the gastric antrum and a multilumen tube in the duodenum under fluoroscopic guidance. Gastric emptying (GE) and intestinal water flux (WF) were measured during 85 min of cycle exercise at 60.6 +/- 3.7% VO2max (x +/- SE) in a 22 degrees C environment. Subjects ingested a total of 23 ml.kg-1 body weight (2005 +/- 187 ml) of a 6% isotonic carbohydrate-electrolyte solution by drinking 396 +/- 34 ml 5 min prior to exercise followed by 198 +/- 17 ml every 10 min during exercise. Mean stomach volume (312 +/- 80 ml) and GE (19.7 +/- 2.0 ml.min-1) did not change significantly after the initial 35 min equilibration period. Mean WF during oral ingestion of the solution (19.5 +/- 2.6 ml.cm-1.h-1) did not differ significantly from mean WF (16.4 +/- 1.9 ml.cm-1.h-1) during perfusion of the same solution directly into the duodenum at a rate equal to each subject's GE rate. Total solute flux (mmol.cm-1.h-1) was not different between drinking (4.1 +/- 1.3) and infusion (3.8 +/- 1.0) trials, nor were the changes in plasma volume. Urine production immediately following the exercise bout was unchanged between drinking (89.1 +/- 27.5 ml) and perfusion (88.5 +/- 24.2) experiments. These data indicate that: 1) relatively constant stomach volumes can be maintained over a prolonged period of time and can produce relatively constant GE rates, and 2) intestinal absorption of an isotonic carbohydrate-electrolyte beverage can be accurately determined by a modified segmental perfusion technique employing ingestion rather than intestinal perfusion. SN - 0172-4622 UR - https://www.unboundmedicine.com/medline/citation/8775576/Simultaneous_determination_of_gastric_emptying_and_intestinal_absorption_during_cycle_exercise_in_humans_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-972807 DB - PRIME DP - Unbound Medicine ER -