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Common carotid intima-media thickness as an indicator of atherosclerosis at other sites of the carotid artery. The Rotterdam Study.
Ann Epidemiol 1996; 6(2):147-53AE

Abstract

To evaluate the association between common carotid intima-media thickness and noninvasively assessed atherosclerosis elsewhere in the carotid artery, we used data from the Rotterdam Study, a single-center population-based, prospective follow-up study among 7983 subjects aged 55 years or older. Baseline measurements included ultrasonographic evaluation of the vessel wall characteristics of the carotid arteries, that is, assessment of the presence of atherosclerotic lesions, measurement of common carotid intima-media thickness, and determination of the presence of hemodynamically significant stenosis. The present analysis is based on data obtained from the first 1000 participants. The results were adjusted for age and gender. An increase of 1 standard deviation in common carotid intima-media thickness (0.19 mm) doubled the risk of plaques in the carotid bifurcation: odds ratio 2.0 (95% confidence interval (CI): 1.6, 2.4). For hemodynamically significant stenosis of the right internal carotid artery (> or = 50%), a 1.4 (95% CI: 1.0, 2.0) increased risk was found. The risk of atherosclerotic plaques in the bifurcation in subjects with an intima-media thickness above 0.89 mm (upper quintile) relative to those with an intima-media thickness below 0.63 mm (lowest quintile) was 6.0 (95% CI: 3.5, 10.2). For internal carotid artery stenosis, a relative risk of 2.8 (95% CI 0.5, 15.7) was found. The findings of the present study provide evidence that increased common carotid intima-media thickness indicates atherosclerosis at other sites of the carotid artery. This study lends support to the view that noninvasively assessed increased intima-media thickness of the distal common carotid artery is an indicator of generalized atherosclerosis.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8775595

Citation

Bots, M L., et al. "Common Carotid Intima-media Thickness as an Indicator of Atherosclerosis at Other Sites of the Carotid Artery. the Rotterdam Study." Annals of Epidemiology, vol. 6, no. 2, 1996, pp. 147-53.
Bots ML, Hofman A, De Jong PT, et al. Common carotid intima-media thickness as an indicator of atherosclerosis at other sites of the carotid artery. The Rotterdam Study. Ann Epidemiol. 1996;6(2):147-53.
Bots, M. L., Hofman, A., De Jong, P. T., & Grobbee, D. E. (1996). Common carotid intima-media thickness as an indicator of atherosclerosis at other sites of the carotid artery. The Rotterdam Study. Annals of Epidemiology, 6(2), pp. 147-53.
Bots ML, et al. Common Carotid Intima-media Thickness as an Indicator of Atherosclerosis at Other Sites of the Carotid Artery. the Rotterdam Study. Ann Epidemiol. 1996;6(2):147-53. PubMed PMID: 8775595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Common carotid intima-media thickness as an indicator of atherosclerosis at other sites of the carotid artery. The Rotterdam Study. AU - Bots,M L, AU - Hofman,A, AU - De Jong,P T, AU - Grobbee,D E, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 147 EP - 53 JF - Annals of epidemiology JO - Ann Epidemiol VL - 6 IS - 2 N2 - To evaluate the association between common carotid intima-media thickness and noninvasively assessed atherosclerosis elsewhere in the carotid artery, we used data from the Rotterdam Study, a single-center population-based, prospective follow-up study among 7983 subjects aged 55 years or older. Baseline measurements included ultrasonographic evaluation of the vessel wall characteristics of the carotid arteries, that is, assessment of the presence of atherosclerotic lesions, measurement of common carotid intima-media thickness, and determination of the presence of hemodynamically significant stenosis. The present analysis is based on data obtained from the first 1000 participants. The results were adjusted for age and gender. An increase of 1 standard deviation in common carotid intima-media thickness (0.19 mm) doubled the risk of plaques in the carotid bifurcation: odds ratio 2.0 (95% confidence interval (CI): 1.6, 2.4). For hemodynamically significant stenosis of the right internal carotid artery (> or = 50%), a 1.4 (95% CI: 1.0, 2.0) increased risk was found. The risk of atherosclerotic plaques in the bifurcation in subjects with an intima-media thickness above 0.89 mm (upper quintile) relative to those with an intima-media thickness below 0.63 mm (lowest quintile) was 6.0 (95% CI: 3.5, 10.2). For internal carotid artery stenosis, a relative risk of 2.8 (95% CI 0.5, 15.7) was found. The findings of the present study provide evidence that increased common carotid intima-media thickness indicates atherosclerosis at other sites of the carotid artery. This study lends support to the view that noninvasively assessed increased intima-media thickness of the distal common carotid artery is an indicator of generalized atherosclerosis. SN - 1047-2797 UR - https://www.unboundmedicine.com/medline/citation/8775595/Common_carotid_intima_media_thickness_as_an_indicator_of_atherosclerosis_at_other_sites_of_the_carotid_artery__The_Rotterdam_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/1047-2797(96)00001-4 DB - PRIME DP - Unbound Medicine ER -