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Use of molecular methods in the early diagnosis of familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer.
Ann Acad Med Singapore. 1996 Jan; 25(1):64-70.AA

Abstract

Familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC) are the most well-defined heritable conditions which predispose to colorectal cancer at a young age. Significant progress in understanding the pathogenesis of FAP and HNPCC has led to the development of techniques which can be used for the diagnosis of these two conditions. In this article, the technical aspects and clinical applications of molecular methods such as linkage analysis, mutational analysis and in vitro synthesised-protein assay for FAP and microsatellite instability or replication error (RER) assay for HNPCC are described and discussed. The potential of such molecular tests is the identification of affected individuals for proper surveillance and management as well as the identification of non-affected individuals to free them from the trauma of uncertainty and repeated unnecessary colonoscopies.

Authors+Show Affiliations

Department of Colorectal Surgery, Singapore General Hospital, Singapore.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

8779549

Citation

Khine, K, et al. "Use of Molecular Methods in the Early Diagnosis of Familial Adenomatous Polyposis and Hereditary Nonpolyposis Colorectal Cancer." Annals of the Academy of Medicine, Singapore, vol. 25, no. 1, 1996, pp. 64-70.
Khine K, Smith DR, Goh HS. Use of molecular methods in the early diagnosis of familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer. Ann Acad Med Singap. 1996;25(1):64-70.
Khine, K., Smith, D. R., & Goh, H. S. (1996). Use of molecular methods in the early diagnosis of familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer. Annals of the Academy of Medicine, Singapore, 25(1), 64-70.
Khine K, Smith DR, Goh HS. Use of Molecular Methods in the Early Diagnosis of Familial Adenomatous Polyposis and Hereditary Nonpolyposis Colorectal Cancer. Ann Acad Med Singap. 1996;25(1):64-70. PubMed PMID: 8779549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of molecular methods in the early diagnosis of familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer. AU - Khine,K, AU - Smith,D R, AU - Goh,H S, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 64 EP - 70 JF - Annals of the Academy of Medicine, Singapore JO - Ann. Acad. Med. Singap. VL - 25 IS - 1 N2 - Familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC) are the most well-defined heritable conditions which predispose to colorectal cancer at a young age. Significant progress in understanding the pathogenesis of FAP and HNPCC has led to the development of techniques which can be used for the diagnosis of these two conditions. In this article, the technical aspects and clinical applications of molecular methods such as linkage analysis, mutational analysis and in vitro synthesised-protein assay for FAP and microsatellite instability or replication error (RER) assay for HNPCC are described and discussed. The potential of such molecular tests is the identification of affected individuals for proper surveillance and management as well as the identification of non-affected individuals to free them from the trauma of uncertainty and repeated unnecessary colonoscopies. SN - 0304-4602 UR - https://www.unboundmedicine.com/medline/citation/8779549/Use_of_molecular_methods_in_the_early_diagnosis_of_familial_adenomatous_polyposis_and_hereditary_nonpolyposis_colorectal_cancer_ L2 - http://www.diseaseinfosearch.org/result/2766 DB - PRIME DP - Unbound Medicine ER -