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The effects of chronic naltrexone treatment in young autistic children: a double-blind placebo-controlled crossover study.
Biol Psychiatry. 1996 Jun 15; 39(12):1023-31.BP

Abstract

In a double-blind placebo-controlled crossover trial 23 autistic children, aged 3-7 years, were treated with a mean daily dosage of 1 mg/kg naltrexone for 4 weeks. Drug effects were monitored with behavior checklists rated by parents and teachers, and ethological playroom observations. On average, parents' checklists and playroom data could not differentiate between naltrexone treatment and placebo treatment; however, teachers significantly favored naltrexone treatment. They reported a decrease in hyperactivity and irritability. No effects of naltrexone on social and stereotypic behavior could be demonstrated.

Authors+Show Affiliations

Department of Child Psychiatry, University of Utrecht, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8780837

Citation

Willemsen-Swinkels, S H., et al. "The Effects of Chronic Naltrexone Treatment in Young Autistic Children: a Double-blind Placebo-controlled Crossover Study." Biological Psychiatry, vol. 39, no. 12, 1996, pp. 1023-31.
Willemsen-Swinkels SH, Buitelaar JK, van Engeland H. The effects of chronic naltrexone treatment in young autistic children: a double-blind placebo-controlled crossover study. Biol Psychiatry. 1996;39(12):1023-31.
Willemsen-Swinkels, S. H., Buitelaar, J. K., & van Engeland, H. (1996). The effects of chronic naltrexone treatment in young autistic children: a double-blind placebo-controlled crossover study. Biological Psychiatry, 39(12), 1023-31.
Willemsen-Swinkels SH, Buitelaar JK, van Engeland H. The Effects of Chronic Naltrexone Treatment in Young Autistic Children: a Double-blind Placebo-controlled Crossover Study. Biol Psychiatry. 1996 Jun 15;39(12):1023-31. PubMed PMID: 8780837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of chronic naltrexone treatment in young autistic children: a double-blind placebo-controlled crossover study. AU - Willemsen-Swinkels,S H, AU - Buitelaar,J K, AU - van Engeland,H, PY - 1996/6/15/pubmed PY - 1996/6/15/medline PY - 1996/6/15/entrez SP - 1023 EP - 31 JF - Biological psychiatry JO - Biol Psychiatry VL - 39 IS - 12 N2 - In a double-blind placebo-controlled crossover trial 23 autistic children, aged 3-7 years, were treated with a mean daily dosage of 1 mg/kg naltrexone for 4 weeks. Drug effects were monitored with behavior checklists rated by parents and teachers, and ethological playroom observations. On average, parents' checklists and playroom data could not differentiate between naltrexone treatment and placebo treatment; however, teachers significantly favored naltrexone treatment. They reported a decrease in hyperactivity and irritability. No effects of naltrexone on social and stereotypic behavior could be demonstrated. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/8780837/The_effects_of_chronic_naltrexone_treatment_in_young_autistic_children:_a_double_blind_placebo_controlled_crossover_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-3223(95)00297-9 DB - PRIME DP - Unbound Medicine ER -