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A population-based study of endometrial cancer and familial risk in younger women. Cancer and Steroid Hormone Study Group.

Abstract

Endometrial cancer remains an important cause of morbidity and mortality in the United States, and recent genetic evidence supports the hypothesis that hormonal dysregulation is not the only important risk factor for this tumor. This multicenter, population-based case-control study investigated familial aggregation of endometrial cancer and other cancers. Cases were 455 women 20-54 years of age diagnosed with histologically confirmed primary epithelial carcinoma of the endometrium. Controls consisted of 3216 women 20-54 years of age identified by random-digit dialing. Family histories of cancer in female relatives were obtained by interview of cases and controls. Endometrial cancer in a first-degree female relative increased the risk of endometrial cancer by nearly 3-fold [odds ratio (OR), 2.8; 95% confidence interval (CI), 1.9-4.2]. Cases also reported significantly more colorectal cancer in family members than did controls (OR, 1.9; 95% CI, 1.1-3.3). Family history of cancer of the cervix, lung, ovary, and thyroid was not significantly associated with endometrial cancer, and breast cancer was not related unless more than one relative was affected. Family history of endometrial cancer is an independent risk factor for cancer of the endometrium. In addition, the observed association with a family history of colorectal cancer suggests that genes important in familial colorectal cancer may have substantial implications for endometrial cancer. Nearly 5% of incident endometrial cancer among women between the ages of 20 and 54 may be attributable to a family history of endometrial cancer, and 2% may be related to colorectal cancer.

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  • Authors+Show Affiliations

    ,

    Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21287-8936, USA.

    Source

    MeSH

    Adult
    Carcinoma
    Case-Control Studies
    Colorectal Neoplasms, Hereditary Nonpolyposis
    Confidence Intervals
    Cross-Sectional Studies
    Endometrial Neoplasms
    Female
    Humans
    Incidence
    Middle Aged
    Odds Ratio
    Risk Factors
    United States

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    8781735

    Citation

    Gruber, S B., and W D. Thompson. "A Population-based Study of Endometrial Cancer and Familial Risk in Younger Women. Cancer and Steroid Hormone Study Group." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 5, no. 6, 1996, pp. 411-7.
    Gruber SB, Thompson WD. A population-based study of endometrial cancer and familial risk in younger women. Cancer and Steroid Hormone Study Group. Cancer Epidemiol Biomarkers Prev. 1996;5(6):411-7.
    Gruber, S. B., & Thompson, W. D. (1996). A population-based study of endometrial cancer and familial risk in younger women. Cancer and Steroid Hormone Study Group. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 5(6), pp. 411-7.
    Gruber SB, Thompson WD. A Population-based Study of Endometrial Cancer and Familial Risk in Younger Women. Cancer and Steroid Hormone Study Group. Cancer Epidemiol Biomarkers Prev. 1996;5(6):411-7. PubMed PMID: 8781735.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A population-based study of endometrial cancer and familial risk in younger women. Cancer and Steroid Hormone Study Group. AU - Gruber,S B, AU - Thompson,W D, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 411 EP - 7 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 5 IS - 6 N2 - Endometrial cancer remains an important cause of morbidity and mortality in the United States, and recent genetic evidence supports the hypothesis that hormonal dysregulation is not the only important risk factor for this tumor. This multicenter, population-based case-control study investigated familial aggregation of endometrial cancer and other cancers. Cases were 455 women 20-54 years of age diagnosed with histologically confirmed primary epithelial carcinoma of the endometrium. Controls consisted of 3216 women 20-54 years of age identified by random-digit dialing. Family histories of cancer in female relatives were obtained by interview of cases and controls. Endometrial cancer in a first-degree female relative increased the risk of endometrial cancer by nearly 3-fold [odds ratio (OR), 2.8; 95% confidence interval (CI), 1.9-4.2]. Cases also reported significantly more colorectal cancer in family members than did controls (OR, 1.9; 95% CI, 1.1-3.3). Family history of cancer of the cervix, lung, ovary, and thyroid was not significantly associated with endometrial cancer, and breast cancer was not related unless more than one relative was affected. Family history of endometrial cancer is an independent risk factor for cancer of the endometrium. In addition, the observed association with a family history of colorectal cancer suggests that genes important in familial colorectal cancer may have substantial implications for endometrial cancer. Nearly 5% of incident endometrial cancer among women between the ages of 20 and 54 may be attributable to a family history of endometrial cancer, and 2% may be related to colorectal cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/8781735/A_population_based_study_of_endometrial_cancer_and_familial_risk_in_younger_women__Cancer_and_Steroid_Hormone_Study_Group_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=8781735 DB - PRIME DP - Unbound Medicine ER -