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Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides.
Nat Genet. 1996 Sep; 14(1):55-61.NGen

Abstract

The apolipoprotein E (APOE) E4 allele is associated with Alzheimer's disease, cardiovascular disease, and decreased longevity. To probe the mechanism of these associations, cell lines were created which secrete each apoE isoform. ApoE conditioned media, purified apoE, and commercially obtained apoE protected B12 cells from hydrogen peroxide cytotoxicity with E2 > E3 > E4. Physiological levels of apoE protected cells from beta-amyloid peptides, while higher doses of apoE led to increased cytotoxicity. E2 > E3 > E4 possessed antioxidant activity, and apoE bound certain metal ions. The decreased antioxidant activity of E4 could contribute to its association with Alzheimer's disease, cardiovascular disease and decreased longevity.

Authors+Show Affiliations

Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, New York 10021, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8782820

Citation

Miyata, M, and J D. Smith. "Apolipoprotein E Allele-specific Antioxidant Activity and Effects On Cytotoxicity By Oxidative Insults and Beta-amyloid Peptides." Nature Genetics, vol. 14, no. 1, 1996, pp. 55-61.
Miyata M, Smith JD. Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. Nat Genet. 1996;14(1):55-61.
Miyata, M., & Smith, J. D. (1996). Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. Nature Genetics, 14(1), 55-61.
Miyata M, Smith JD. Apolipoprotein E Allele-specific Antioxidant Activity and Effects On Cytotoxicity By Oxidative Insults and Beta-amyloid Peptides. Nat Genet. 1996;14(1):55-61. PubMed PMID: 8782820.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. AU - Miyata,M, AU - Smith,J D, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 55 EP - 61 JF - Nature genetics JO - Nat Genet VL - 14 IS - 1 N2 - The apolipoprotein E (APOE) E4 allele is associated with Alzheimer's disease, cardiovascular disease, and decreased longevity. To probe the mechanism of these associations, cell lines were created which secrete each apoE isoform. ApoE conditioned media, purified apoE, and commercially obtained apoE protected B12 cells from hydrogen peroxide cytotoxicity with E2 > E3 > E4. Physiological levels of apoE protected cells from beta-amyloid peptides, while higher doses of apoE led to increased cytotoxicity. E2 > E3 > E4 possessed antioxidant activity, and apoE bound certain metal ions. The decreased antioxidant activity of E4 could contribute to its association with Alzheimer's disease, cardiovascular disease and decreased longevity. SN - 1061-4036 UR - https://www.unboundmedicine.com/medline/citation/8782820/Apolipoprotein_E_allele_specific_antioxidant_activity_and_effects_on_cytotoxicity_by_oxidative_insults_and_beta_amyloid_peptides_ L2 - https://doi.org/10.1038/ng0996-55 DB - PRIME DP - Unbound Medicine ER -