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Screening for coeliac disease in Dutch children with associated diseases.
Acta Paediatr Suppl 1996; 412:52-3AP

Abstract

Our objective was to assess the frequency of coeliac disease in children with associated disorders in the province of "Zuid-Holland". The Netherlands. We therefore screened 115 children with Down's syndrome, 62 children with juvenile rheumatoid arthritis (JRA) and 46 children with diabetes mellitus for CD using the IgA-class of antigliadin, antiendomysium and antireticulin antibodies in serum, and a functional sugar absorption test. The antiendomysium antibody test was the screening test that performed the best. Every patient who has at least one positive test underwent a jejunal biopsy for the diagnosis of CD. No association could be demonstrated between CD and diabetes mellitus. The frequency of CD in Down's syndrome was 7.0%, which is much higher than that found from screening the general population. CD was found in one child with JRA (1.5%), who also had Down's syndrome. We recommend screening for CD in all persons with Down's syndrome using at least the antiendomysium antibody test.

Authors+Show Affiliations

Department of Paediatrics, University Hospital Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8783759

Citation

George, E K., et al. "Screening for Coeliac Disease in Dutch Children With Associated Diseases." Acta Paediatrica (Oslo, Norway : 1992). Supplement, vol. 412, 1996, pp. 52-3.
George EK, Mearin ML, Bouquet J, et al. Screening for coeliac disease in Dutch children with associated diseases. Acta Paediatr Suppl. 1996;412:52-3.
George, E. K., Mearin, M. L., Bouquet, J., von Blomberg, B. M., Stapel, S. O., van Elburg, R. M., ... Oostdijk, W. (1996). Screening for coeliac disease in Dutch children with associated diseases. Acta Paediatrica (Oslo, Norway : 1992). Supplement, 412, pp. 52-3.
George EK, et al. Screening for Coeliac Disease in Dutch Children With Associated Diseases. Acta Paediatr Suppl. 1996;412:52-3. PubMed PMID: 8783759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening for coeliac disease in Dutch children with associated diseases. AU - George,E K, AU - Mearin,M L, AU - Bouquet,J, AU - von Blomberg,B M, AU - Stapel,S O, AU - van Elburg,R M, AU - de Graaf,E A, AU - Hertzberger-ten Cate,R, AU - van Suijlekom-Smith,L W, AU - Reeser,H M, AU - Oostdijk,W, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 52 EP - 3 JF - Acta paediatrica (Oslo, Norway : 1992). Supplement JO - Acta Paediatr Suppl VL - 412 N2 - Our objective was to assess the frequency of coeliac disease in children with associated disorders in the province of "Zuid-Holland". The Netherlands. We therefore screened 115 children with Down's syndrome, 62 children with juvenile rheumatoid arthritis (JRA) and 46 children with diabetes mellitus for CD using the IgA-class of antigliadin, antiendomysium and antireticulin antibodies in serum, and a functional sugar absorption test. The antiendomysium antibody test was the screening test that performed the best. Every patient who has at least one positive test underwent a jejunal biopsy for the diagnosis of CD. No association could be demonstrated between CD and diabetes mellitus. The frequency of CD in Down's syndrome was 7.0%, which is much higher than that found from screening the general population. CD was found in one child with JRA (1.5%), who also had Down's syndrome. We recommend screening for CD in all persons with Down's syndrome using at least the antiendomysium antibody test. SN - 0803-5326 UR - https://www.unboundmedicine.com/medline/citation/8783759/Screening_for_coeliac_disease_in_Dutch_children_with_associated_diseases_ L2 - https://medlineplus.gov/downsyndrome.html DB - PRIME DP - Unbound Medicine ER -