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Serological screening (antigliadin and antiendomysium antibodies) for non-overt coeliac disease in children of short stature.
Acta Paediatr Suppl 1996; 412:54-5AP

Abstract

This study aimed to assess the value of IgA-antigliadin and antiendomysium antibodies for coeliac disease screening in children with short stature. In 118 children with height less than the 3rd percentile for age preliminary work-up included absorption, hormonal and genetic studies, sweat test, X-ray for bone age, serum immunoglobulin levels and antigliadin antibodies. In 65 patients antiendomysium antibody and a small-intestinal biopsy were performed. Forty-three children had a normal mucosa and 22 a subtotal villous atrophy. Three coeliac children were negative for both antigliadin and antiendomysium antibodies; one further 11-year-old boy was negative only for antiendomysium antibodies. Sensitivity and specificity for antigliadin antibodies were 94.75% and 93%, respectively, and for antiendomysium antibodies 88.3% and 90.5%. Our results show that the use of antiendomysium antibodies as a confirmatory test to select patients for biopsy could result in coeliac disease going undiagnosed in adolescents.

Authors+Show Affiliations

Gastroenterology Unit H. Infantil La Fe, Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8783760

Citation

de Lecea, A, et al. "Serological Screening (antigliadin and Antiendomysium Antibodies) for Non-overt Coeliac Disease in Children of Short Stature." Acta Paediatrica (Oslo, Norway : 1992). Supplement, vol. 412, 1996, pp. 54-5.
de Lecea A, Ribes-Koninckx C, Polanco I, et al. Serological screening (antigliadin and antiendomysium antibodies) for non-overt coeliac disease in children of short stature. Acta Paediatr Suppl. 1996;412:54-5.
de Lecea, A., Ribes-Koninckx, C., Polanco, I., & Calvete, J. F. (1996). Serological screening (antigliadin and antiendomysium antibodies) for non-overt coeliac disease in children of short stature. Acta Paediatrica (Oslo, Norway : 1992). Supplement, 412, pp. 54-5.
de Lecea A, et al. Serological Screening (antigliadin and Antiendomysium Antibodies) for Non-overt Coeliac Disease in Children of Short Stature. Acta Paediatr Suppl. 1996;412:54-5. PubMed PMID: 8783760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serological screening (antigliadin and antiendomysium antibodies) for non-overt coeliac disease in children of short stature. AU - de Lecea,A, AU - Ribes-Koninckx,C, AU - Polanco,I, AU - Calvete,J F, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 54 EP - 5 JF - Acta paediatrica (Oslo, Norway : 1992). Supplement JO - Acta Paediatr Suppl VL - 412 N2 - This study aimed to assess the value of IgA-antigliadin and antiendomysium antibodies for coeliac disease screening in children with short stature. In 118 children with height less than the 3rd percentile for age preliminary work-up included absorption, hormonal and genetic studies, sweat test, X-ray for bone age, serum immunoglobulin levels and antigliadin antibodies. In 65 patients antiendomysium antibody and a small-intestinal biopsy were performed. Forty-three children had a normal mucosa and 22 a subtotal villous atrophy. Three coeliac children were negative for both antigliadin and antiendomysium antibodies; one further 11-year-old boy was negative only for antiendomysium antibodies. Sensitivity and specificity for antigliadin antibodies were 94.75% and 93%, respectively, and for antiendomysium antibodies 88.3% and 90.5%. Our results show that the use of antiendomysium antibodies as a confirmatory test to select patients for biopsy could result in coeliac disease going undiagnosed in adolescents. SN - 0803-5326 UR - https://www.unboundmedicine.com/medline/citation/8783760/Serological_screening__antigliadin_and_antiendomysium_antibodies__for_non_overt_coeliac_disease_in_children_of_short_stature_ L2 - http://www.diseaseinfosearch.org/result/6557 DB - PRIME DP - Unbound Medicine ER -