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Technetium-99m-sulfur colloid for lymphoscintigraphy: effects of preparation parameters.
J Nucl Med. 1996 Sep; 37(9):1575-8.JN

Abstract

There has been a resurgence in the use of lymphoscintigraphy for the external detection of lymph nodes for metastatic melanoma and breast tumors. Technetium-99m-antimony trisulfide colloid was the radiopharmaceutical developed for this procedure and was found to have a narrow distribution of small particles, 0.003-0.03 microns, but it was never approved by the FDA. Technetium-99m-sulfur colloid also forms particles and this article reports on the effects different preparation parameters have on its particle size distribution and stability.

METHODS

Four groups of kits were evaluated, kits which utilized: (a) a reduced heating protocol with a new 99mTc-elution, (b) a reduced heating protocol with an old 99mTc-elution, (c) a prolonged heating protocol with a new 99mTc-elution and (d) a prolonged heating protocol with an old 99mTc-elution. The particle size distribution and the stability of the different 99mTc-sulfur colloid kit preparations were evaluated over 6 hr utilizing polycarbonate filters ranging from 0.03 to 10 microns.

RESULTS

In vitro studies demonstrated no significant change in the particle size distribution over a 6-hr period and all 99mTc-sulfur colloid preparations had a bimodal particle size distribution pattern. Importantly, heating the kit for shorter periods of times utilizing [99mTc]pertechnetate, which had a longer ingrowth of [99mTc]pertechnetate, produced a formulation which had the largest percentage of particles smaller than 0.03 microns.

CONCLUSION

In our clinical setting, 99mTc-sulfur colloid prepared with the reduced heating protocol and utilizing [99mTc]pertechnetate, which has the highest ingrowth of [99mTc]pertechnetate has proved to be an excellent agent for lymphoscintigraphy studies. This preparation has demonstrated rapid movement of the particles from the primary site to the lymph nodes in over 97% (106/109) of the patients we have studied.

Links

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Authors+Show Affiliations

Eshima D
Department of Radiology, Emory University, Atlanta, Georgia 30322, USA.
Eshima LA
No affiliation info available
Gotti NM
No affiliation info available
Herda SC
No affiliation info available
Algozine CA
No affiliation info available
Burris TG
No affiliation info available
Vansant JP
No affiliation info available
Alazraki NP
No affiliation info available
Taylor AT
No affiliation info available

MeSH

HumansLymph NodesParticle SizeRadionuclide ImagingReagent Kits, DiagnosticTechnetium Tc 99m Sulfur ColloidTime FactorsTissue Distribution

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8790222

Citation

Eshima, D, et al. "Technetium-99m-sulfur Colloid for Lymphoscintigraphy: Effects of Preparation Parameters." Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, vol. 37, no. 9, 1996, pp. 1575-8.
Eshima D, Eshima LA, Gotti NM, et al. Technetium-99m-sulfur colloid for lymphoscintigraphy: effects of preparation parameters. J Nucl Med. 1996;37(9):1575-8.
Eshima, D., Eshima, L. A., Gotti, N. M., Herda, S. C., Algozine, C. A., Burris, T. G., Vansant, J. P., Alazraki, N. P., & Taylor, A. T. (1996). Technetium-99m-sulfur colloid for lymphoscintigraphy: effects of preparation parameters. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 37(9), 1575-8.
Eshima D, et al. Technetium-99m-sulfur Colloid for Lymphoscintigraphy: Effects of Preparation Parameters. J Nucl Med. 1996;37(9):1575-8. PubMed PMID: 8790222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Technetium-99m-sulfur colloid for lymphoscintigraphy: effects of preparation parameters. AU - Eshima,D, AU - Eshima,L A, AU - Gotti,N M, AU - Herda,S C, AU - Algozine,C A, AU - Burris,T G, AU - Vansant,J P, AU - Alazraki,N P, AU - Taylor,A T, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 1575 EP - 8 JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine JO - J Nucl Med VL - 37 IS - 9 N2 - UNLABELLED: There has been a resurgence in the use of lymphoscintigraphy for the external detection of lymph nodes for metastatic melanoma and breast tumors. Technetium-99m-antimony trisulfide colloid was the radiopharmaceutical developed for this procedure and was found to have a narrow distribution of small particles, 0.003-0.03 microns, but it was never approved by the FDA. Technetium-99m-sulfur colloid also forms particles and this article reports on the effects different preparation parameters have on its particle size distribution and stability. METHODS: Four groups of kits were evaluated, kits which utilized: (a) a reduced heating protocol with a new 99mTc-elution, (b) a reduced heating protocol with an old 99mTc-elution, (c) a prolonged heating protocol with a new 99mTc-elution and (d) a prolonged heating protocol with an old 99mTc-elution. The particle size distribution and the stability of the different 99mTc-sulfur colloid kit preparations were evaluated over 6 hr utilizing polycarbonate filters ranging from 0.03 to 10 microns. RESULTS: In vitro studies demonstrated no significant change in the particle size distribution over a 6-hr period and all 99mTc-sulfur colloid preparations had a bimodal particle size distribution pattern. Importantly, heating the kit for shorter periods of times utilizing [99mTc]pertechnetate, which had a longer ingrowth of [99mTc]pertechnetate, produced a formulation which had the largest percentage of particles smaller than 0.03 microns. CONCLUSION: In our clinical setting, 99mTc-sulfur colloid prepared with the reduced heating protocol and utilizing [99mTc]pertechnetate, which has the highest ingrowth of [99mTc]pertechnetate has proved to be an excellent agent for lymphoscintigraphy studies. This preparation has demonstrated rapid movement of the particles from the primary site to the lymph nodes in over 97% (106/109) of the patients we have studied. SN - 0161-5505 UR - https://www.unboundmedicine.com/medline/citation/8790222/Technetium_99m_sulfur_colloid_for_lymphoscintigraphy:_effects_of_preparation_parameters_ L2 - http://jnm.snmjournals.org/cgi/pmidlookup?view=long&pmid=8790222 DB - PRIME DP - Unbound Medicine ER -