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Nocturnal plasma melatonin levels after flunitrazepam administration in healthy subjects.
Eur Neuropsychopharmacol 1996; 6(2):149-53EN

Abstract

Polysomnographic sleep patterns and melatonin secretion were investigated in 5 young (age 25.6 +/- 1.1 years) and 5 middle-aged (age 49.4 +/- 5.4 years) healthy male subjects after intravenous administration of 1 mg flunitrazepam and placebo in a randomized, double-blind and cross-over setting. The area under the curve (AUC) of total nocturnal melatonin plasma concentration decreased 23.3 +/- 11.5% in young subjects (P < or = 0.05) and 39.3 +/- 5.2% in middle-aged subjects (P < or = 0.05) after flunitrazepam infusion compared with placebo infusion. Differences in nocturnal peak values of melatonin were 5.4 +/- 22.0% in young subjects (not significant) and 34.0 +/- 14.7% in middle-aged subjects (p < or = 0.05). Flunitrazepam significantly (P < or = 0.05) improved sleep latency and the number of sleep stage changes in the group of all subjects. These results show that, although the benzodiazepine flunitrazepam improves sleep, it reduces the nocturnal secretion of melatonin, and therefore alters the circadian rhythm of a hormone which is supposed to play a special role in circadian sleep-wake rhythmicity.

Authors+Show Affiliations

Department of Psychiatry, University of Göttingen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8791041

Citation

Hajak, G, et al. "Nocturnal Plasma Melatonin Levels After Flunitrazepam Administration in Healthy Subjects." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 6, no. 2, 1996, pp. 149-53.
Hajak G, Rodenbeck A, Bandelow B, et al. Nocturnal plasma melatonin levels after flunitrazepam administration in healthy subjects. Eur Neuropsychopharmacol. 1996;6(2):149-53.
Hajak, G., Rodenbeck, A., Bandelow, B., Friedrichs, S., Huether, G., & Rüther, E. (1996). Nocturnal plasma melatonin levels after flunitrazepam administration in healthy subjects. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 6(2), pp. 149-53.
Hajak G, et al. Nocturnal Plasma Melatonin Levels After Flunitrazepam Administration in Healthy Subjects. Eur Neuropsychopharmacol. 1996;6(2):149-53. PubMed PMID: 8791041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nocturnal plasma melatonin levels after flunitrazepam administration in healthy subjects. AU - Hajak,G, AU - Rodenbeck,A, AU - Bandelow,B, AU - Friedrichs,S, AU - Huether,G, AU - Rüther,E, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 149 EP - 53 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 6 IS - 2 N2 - Polysomnographic sleep patterns and melatonin secretion were investigated in 5 young (age 25.6 +/- 1.1 years) and 5 middle-aged (age 49.4 +/- 5.4 years) healthy male subjects after intravenous administration of 1 mg flunitrazepam and placebo in a randomized, double-blind and cross-over setting. The area under the curve (AUC) of total nocturnal melatonin plasma concentration decreased 23.3 +/- 11.5% in young subjects (P < or = 0.05) and 39.3 +/- 5.2% in middle-aged subjects (P < or = 0.05) after flunitrazepam infusion compared with placebo infusion. Differences in nocturnal peak values of melatonin were 5.4 +/- 22.0% in young subjects (not significant) and 34.0 +/- 14.7% in middle-aged subjects (p < or = 0.05). Flunitrazepam significantly (P < or = 0.05) improved sleep latency and the number of sleep stage changes in the group of all subjects. These results show that, although the benzodiazepine flunitrazepam improves sleep, it reduces the nocturnal secretion of melatonin, and therefore alters the circadian rhythm of a hormone which is supposed to play a special role in circadian sleep-wake rhythmicity. SN - 0924-977X UR - https://www.unboundmedicine.com/medline/citation/8791041/Nocturnal_plasma_melatonin_levels_after_flunitrazepam_administration_in_healthy_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0924-977X(96)00005-3 DB - PRIME DP - Unbound Medicine ER -