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Nocturnal plasma melatonin levels after flunitrazepam administration in healthy subjects.

Abstract

Polysomnographic sleep patterns and melatonin secretion were investigated in 5 young (age 25.6 +/- 1.1 years) and 5 middle-aged (age 49.4 +/- 5.4 years) healthy male subjects after intravenous administration of 1 mg flunitrazepam and placebo in a randomized, double-blind and cross-over setting. The area under the curve (AUC) of total nocturnal melatonin plasma concentration decreased 23.3 +/- 11.5% in young subjects (P < or = 0.05) and 39.3 +/- 5.2% in middle-aged subjects (P < or = 0.05) after flunitrazepam infusion compared with placebo infusion. Differences in nocturnal peak values of melatonin were 5.4 +/- 22.0% in young subjects (not significant) and 34.0 +/- 14.7% in middle-aged subjects (p < or = 0.05). Flunitrazepam significantly (P < or = 0.05) improved sleep latency and the number of sleep stage changes in the group of all subjects. These results show that, although the benzodiazepine flunitrazepam improves sleep, it reduces the nocturnal secretion of melatonin, and therefore alters the circadian rhythm of a hormone which is supposed to play a special role in circadian sleep-wake rhythmicity.

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  • Authors+Show Affiliations

    ,

    Department of Psychiatry, University of Göttingen, Germany.

    , , , ,

    Source

    MeSH

    Adult
    Anti-Anxiety Agents
    Circadian Rhythm
    Cross-Over Studies
    Double-Blind Method
    Flunitrazepam
    Humans
    Male
    Melatonin
    Middle Aged
    Sleep Stages

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    8791041

    Citation

    Hajak, G, et al. "Nocturnal Plasma Melatonin Levels After Flunitrazepam Administration in Healthy Subjects." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 6, no. 2, 1996, pp. 149-53.
    Hajak G, Rodenbeck A, Bandelow B, et al. Nocturnal plasma melatonin levels after flunitrazepam administration in healthy subjects. Eur Neuropsychopharmacol. 1996;6(2):149-53.
    Hajak, G., Rodenbeck, A., Bandelow, B., Friedrichs, S., Huether, G., & Rüther, E. (1996). Nocturnal plasma melatonin levels after flunitrazepam administration in healthy subjects. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 6(2), pp. 149-53.
    Hajak G, et al. Nocturnal Plasma Melatonin Levels After Flunitrazepam Administration in Healthy Subjects. Eur Neuropsychopharmacol. 1996;6(2):149-53. PubMed PMID: 8791041.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nocturnal plasma melatonin levels after flunitrazepam administration in healthy subjects. AU - Hajak,G, AU - Rodenbeck,A, AU - Bandelow,B, AU - Friedrichs,S, AU - Huether,G, AU - Rüther,E, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 149 EP - 53 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 6 IS - 2 N2 - Polysomnographic sleep patterns and melatonin secretion were investigated in 5 young (age 25.6 +/- 1.1 years) and 5 middle-aged (age 49.4 +/- 5.4 years) healthy male subjects after intravenous administration of 1 mg flunitrazepam and placebo in a randomized, double-blind and cross-over setting. The area under the curve (AUC) of total nocturnal melatonin plasma concentration decreased 23.3 +/- 11.5% in young subjects (P < or = 0.05) and 39.3 +/- 5.2% in middle-aged subjects (P < or = 0.05) after flunitrazepam infusion compared with placebo infusion. Differences in nocturnal peak values of melatonin were 5.4 +/- 22.0% in young subjects (not significant) and 34.0 +/- 14.7% in middle-aged subjects (p < or = 0.05). Flunitrazepam significantly (P < or = 0.05) improved sleep latency and the number of sleep stage changes in the group of all subjects. These results show that, although the benzodiazepine flunitrazepam improves sleep, it reduces the nocturnal secretion of melatonin, and therefore alters the circadian rhythm of a hormone which is supposed to play a special role in circadian sleep-wake rhythmicity. SN - 0924-977X UR - https://www.unboundmedicine.com/medline/citation/8791041/Nocturnal_plasma_melatonin_levels_after_flunitrazepam_administration_in_healthy_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0924-977X(96)00005-3 DB - PRIME DP - Unbound Medicine ER -