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Improvement of lactose digestion in humans by ingestion of unfermented milk containing Bifidobacterium longum.
J Dairy Sci. 1996 May; 79(5):750-7.JD

Abstract

Fifteen lactose malabsorbers were studied to evaluate the effects of consumption of milk containing different strains of Bifidobacterium longum on lactose digestion. Influences of different growth substrates, bile sensitivity, and lactose transport on lactose digestion by bifidobacteria were also investigated. Lactose malabsorption was determined by measuring breath hydrogen excretion of subjects fed four different test milks (three of which contained 5 x 10(8) cfu/ml of B. longum) on 4 different d using a randomized, double-blinded trial. Test milks included 1) 400 ml of lowfat milk (control), 2) 400 ml of milk containing B. longum B6 that had been grown with lactose, 3) 400 ml of milk containing B. longum B6 grown with lactose plus glucose, or 4) 400 ml of milk containing B. longum ATCC 15708 grown with lactose. beta-Galactosidase activity was highest in milk containing B6 grown with lactose but was extremely low in milk containing B6 grown with lactose and glucose. Consumption of milk containing B6 grown with lactose resulted in significantly less hydrogen production and flatulence than occurring after consumption of control milk or the milk containing B6 grown with both lactose and glucose. Hydrogen production after ingestion of 15708 was also significantly lower than hydrogen production after ingestion of the control milk. We concluded that milks containing B. longum might reduce breath hydrogen response and symptoms from lactose malabsorption when the culture is grown in a medium containing only lactose to induce a higher beta-galactosidase level and increase rate of lactose uptake.

Authors+Show Affiliations

Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8792277

Citation

Jiang, T, et al. "Improvement of Lactose Digestion in Humans By Ingestion of Unfermented Milk Containing Bifidobacterium Longum." Journal of Dairy Science, vol. 79, no. 5, 1996, pp. 750-7.
Jiang T, Mustapha A, Savaiano DA. Improvement of lactose digestion in humans by ingestion of unfermented milk containing Bifidobacterium longum. J Dairy Sci. 1996;79(5):750-7.
Jiang, T., Mustapha, A., & Savaiano, D. A. (1996). Improvement of lactose digestion in humans by ingestion of unfermented milk containing Bifidobacterium longum. Journal of Dairy Science, 79(5), 750-7.
Jiang T, Mustapha A, Savaiano DA. Improvement of Lactose Digestion in Humans By Ingestion of Unfermented Milk Containing Bifidobacterium Longum. J Dairy Sci. 1996;79(5):750-7. PubMed PMID: 8792277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvement of lactose digestion in humans by ingestion of unfermented milk containing Bifidobacterium longum. AU - Jiang,T, AU - Mustapha,A, AU - Savaiano,D A, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 750 EP - 7 JF - Journal of dairy science JO - J Dairy Sci VL - 79 IS - 5 N2 - Fifteen lactose malabsorbers were studied to evaluate the effects of consumption of milk containing different strains of Bifidobacterium longum on lactose digestion. Influences of different growth substrates, bile sensitivity, and lactose transport on lactose digestion by bifidobacteria were also investigated. Lactose malabsorption was determined by measuring breath hydrogen excretion of subjects fed four different test milks (three of which contained 5 x 10(8) cfu/ml of B. longum) on 4 different d using a randomized, double-blinded trial. Test milks included 1) 400 ml of lowfat milk (control), 2) 400 ml of milk containing B. longum B6 that had been grown with lactose, 3) 400 ml of milk containing B. longum B6 grown with lactose plus glucose, or 4) 400 ml of milk containing B. longum ATCC 15708 grown with lactose. beta-Galactosidase activity was highest in milk containing B6 grown with lactose but was extremely low in milk containing B6 grown with lactose and glucose. Consumption of milk containing B6 grown with lactose resulted in significantly less hydrogen production and flatulence than occurring after consumption of control milk or the milk containing B6 grown with both lactose and glucose. Hydrogen production after ingestion of 15708 was also significantly lower than hydrogen production after ingestion of the control milk. We concluded that milks containing B. longum might reduce breath hydrogen response and symptoms from lactose malabsorption when the culture is grown in a medium containing only lactose to induce a higher beta-galactosidase level and increase rate of lactose uptake. SN - 0022-0302 UR - https://www.unboundmedicine.com/medline/citation/8792277/Improvement_of_lactose_digestion_in_humans_by_ingestion_of_unfermented_milk_containing_Bifidobacterium_longum_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-0302(96)76422-6 DB - PRIME DP - Unbound Medicine ER -