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Teratogenic effects of selenium compounds on cultured postimplantation rat embryos.
Teratog Carcinog Mutagen. 1996; 16(1):27-36.TC

Abstract

Embryonic susceptibility to selenium (Se) teratogenicity was examined in rats using postimplantation embryo culture. Rat embryos at day 9.5 of gestation were cultured by the roller bottle method for 48 hr in the presence of Se compounds. Sodium selenite, sodium selenate, seleno-DL-methionine, and seleno-DL-cystine were embryolethal at 20, 300, 1,000, and 1,000 microM Se, respectively. All of these compounds caused abnormalities such as deformed optic vesicle and swollen rhombencephalon in the viable embryos. These abnormalities were considered to correspond to in vivo malformations caused by Se in hamster fetuses or in bird embryos. These results indicate that rat embryos are susceptible to Se teratogenicity. It seems that there are differences in potency ranking of Se compounds between rat and bird embryos.

Authors+Show Affiliations

Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8792531

Citation

Usami, M, and Y Ohno. "Teratogenic Effects of Selenium Compounds On Cultured Postimplantation Rat Embryos." Teratogenesis, Carcinogenesis, and Mutagenesis, vol. 16, no. 1, 1996, pp. 27-36.
Usami M, Ohno Y. Teratogenic effects of selenium compounds on cultured postimplantation rat embryos. Teratog, Carcinog Mutagen. 1996;16(1):27-36.
Usami, M., & Ohno, Y. (1996). Teratogenic effects of selenium compounds on cultured postimplantation rat embryos. Teratogenesis, Carcinogenesis, and Mutagenesis, 16(1), 27-36.
Usami M, Ohno Y. Teratogenic Effects of Selenium Compounds On Cultured Postimplantation Rat Embryos. Teratog, Carcinog Mutagen. 1996;16(1):27-36. PubMed PMID: 8792531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Teratogenic effects of selenium compounds on cultured postimplantation rat embryos. AU - Usami,M, AU - Ohno,Y, PY - 1996/1/1/pubmed PY - 2000/6/20/medline PY - 1996/1/1/entrez SP - 27 EP - 36 JF - Teratogenesis, carcinogenesis, and mutagenesis JO - Teratog., Carcinog. Mutagen. VL - 16 IS - 1 N2 - Embryonic susceptibility to selenium (Se) teratogenicity was examined in rats using postimplantation embryo culture. Rat embryos at day 9.5 of gestation were cultured by the roller bottle method for 48 hr in the presence of Se compounds. Sodium selenite, sodium selenate, seleno-DL-methionine, and seleno-DL-cystine were embryolethal at 20, 300, 1,000, and 1,000 microM Se, respectively. All of these compounds caused abnormalities such as deformed optic vesicle and swollen rhombencephalon in the viable embryos. These abnormalities were considered to correspond to in vivo malformations caused by Se in hamster fetuses or in bird embryos. These results indicate that rat embryos are susceptible to Se teratogenicity. It seems that there are differences in potency ranking of Se compounds between rat and bird embryos. SN - 0270-3211 UR - https://www.unboundmedicine.com/medline/citation/8792531/Teratogenic_effects_of_selenium_compounds_on_cultured_postimplantation_rat_embryos_ L2 - https://doi.org/10.1002/(SICI)1520-6866(1996)16:1<27::AID-TCM4>3.0.CO;2-I DB - PRIME DP - Unbound Medicine ER -