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Cercophorins A-C: novel antifungal and cytotoxic metabolites from the coprophilous fungus Cercophora areolata.
J Nat Prod. 1996 Aug; 59(8):765-9.JN

Abstract

Cercophorins A-C (3-5), three novel isocoumarin derivatives with antifungal and cytotoxic activities, have been isolated from the coprophilous fungus Cercophora areolata (JS 166 = UAMH 7495), a colonist of porcupine dung. Two additional new isocoumarins, decarboxy-citrinone (1) and 4-acetyl-8-hydroxy-6-methoxy-5-methylisocoumarin (2), and a known tricothecene mycotoxin, roridin E (6), were also obtained from this species. Compounds 1-6 were isolated from ethyl acetate extracts of mycelia and liquid cultures of C. areolata through bioassay-guided fractionation and are the first metabolites to be reported from a member of the genus Cercophora. Their structures were assigned on the basis of MS, selective INEPT, and 2D-NMR experiments.

Authors+Show Affiliations

Whyte AC
Department of Chemistry, University of Iowa, Iowa City 52242, USA.
Gloer JB
No affiliation info available
Scott JA
No affiliation info available
Malloch D
No affiliation info available

MeSH

Antifungal AgentsAscomycotaBacillus subtilisCandida albicansChromatography, High Pressure LiquidCoumarinsMagnetic Resonance SpectroscopyMass SpectrometrySpectrometry, Mass, Fast Atom BombardmentStaphylococcus aureusStereoisomerismStructure-Activity Relationship

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8792624

Citation

Whyte, A C., et al. "Cercophorins A-C: Novel Antifungal and Cytotoxic Metabolites From the Coprophilous Fungus Cercophora Areolata." Journal of Natural Products, vol. 59, no. 8, 1996, pp. 765-9.
Whyte AC, Gloer JB, Scott JA, et al. Cercophorins A-C: novel antifungal and cytotoxic metabolites from the coprophilous fungus Cercophora areolata. J Nat Prod. 1996;59(8):765-9.
Whyte, A. C., Gloer, J. B., Scott, J. A., & Malloch, D. (1996). Cercophorins A-C: novel antifungal and cytotoxic metabolites from the coprophilous fungus Cercophora areolata. Journal of Natural Products, 59(8), 765-9.
Whyte AC, et al. Cercophorins A-C: Novel Antifungal and Cytotoxic Metabolites From the Coprophilous Fungus Cercophora Areolata. J Nat Prod. 1996;59(8):765-9. PubMed PMID: 8792624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cercophorins A-C: novel antifungal and cytotoxic metabolites from the coprophilous fungus Cercophora areolata. AU - Whyte,A C, AU - Gloer,J B, AU - Scott,J A, AU - Malloch,D, PY - 1996/8/1/pubmed PY - 1996/8/1/medline PY - 1996/8/1/entrez SP - 765 EP - 9 JF - Journal of natural products JO - J Nat Prod VL - 59 IS - 8 N2 - Cercophorins A-C (3-5), three novel isocoumarin derivatives with antifungal and cytotoxic activities, have been isolated from the coprophilous fungus Cercophora areolata (JS 166 = UAMH 7495), a colonist of porcupine dung. Two additional new isocoumarins, decarboxy-citrinone (1) and 4-acetyl-8-hydroxy-6-methoxy-5-methylisocoumarin (2), and a known tricothecene mycotoxin, roridin E (6), were also obtained from this species. Compounds 1-6 were isolated from ethyl acetate extracts of mycelia and liquid cultures of C. areolata through bioassay-guided fractionation and are the first metabolites to be reported from a member of the genus Cercophora. Their structures were assigned on the basis of MS, selective INEPT, and 2D-NMR experiments. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/8792624/Cercophorins_A_C:_novel_antifungal_and_cytotoxic_metabolites_from_the_coprophilous_fungus_Cercophora_areolata_ L2 - https://doi.org/10.1021/np9603232 DB - PRIME DP - Unbound Medicine ER -