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Sensitization of esophageal mucosa by prior acid infusion: effect of decreasing intervals between infusions.
Am J Gastroenterol 1996; 91(9):1745-8AJ

Abstract

OBJECTIVE

To determine the effect of decreasing time intervals between acid exposures on the sensitivity of the esophageal mucosa.

METHODS

Ten healthy subjects with no history of gastroesophageal reflux disease who were symptomatic during a modified Bernstein acid infusion test were recruited for the study. Hydrochloric acid solutions of pH 3, 2, and 1 were sequentially tested. The weakest pH solution that was perceived by the patient was used for the study. The same duration of acid infusions (9 ml/min for 5 min) were made but with decreasing time intervals between each subsequent acid infusion (30-0 min). Esophageal sensation during each of the infusions, the amount of distilled water required to raise intraesophageal pH > 4, and the duration of residual heartburn after pH > 4 were recorded.

RESULTS

Seven of the 10 subjects (70%) were Bernstein-positive to pH 3, two to pH 2, and only one to pH 1 solution. The median time to initial heartburn was significantly reduced only between the initial infusion and the first subsequent acid exposure 30 min later (165 vs 51.5 s, p < 0.009). Subsequent reductions in the time interval between infusions did not significantly reduce the perception threshold. The water required to clear the esophagus to pH > 4 and time required for the residual esophageal sensation to disappear were not significantly altered throughout the study.

CONCLUSIONS

These data suggest that some episodes of reflux may be felt sooner and perhaps more severely despite similar levels of acid burden in the esophagus when sensitization by a prior reflux episode occurs.

Authors+Show Affiliations

Department of Medicine, Graduate Hospital, Philadelphia, Pennsylvania, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8792692

Citation

Siddiqui, M A., et al. "Sensitization of Esophageal Mucosa By Prior Acid Infusion: Effect of Decreasing Intervals Between Infusions." The American Journal of Gastroenterology, vol. 91, no. 9, 1996, pp. 1745-8.
Siddiqui MA, Johnston BT, Leite LP, et al. Sensitization of esophageal mucosa by prior acid infusion: effect of decreasing intervals between infusions. Am J Gastroenterol. 1996;91(9):1745-8.
Siddiqui, M. A., Johnston, B. T., Leite, L. P., Katzka, D. A., & Castell, D. O. (1996). Sensitization of esophageal mucosa by prior acid infusion: effect of decreasing intervals between infusions. The American Journal of Gastroenterology, 91(9), pp. 1745-8.
Siddiqui MA, et al. Sensitization of Esophageal Mucosa By Prior Acid Infusion: Effect of Decreasing Intervals Between Infusions. Am J Gastroenterol. 1996;91(9):1745-8. PubMed PMID: 8792692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitization of esophageal mucosa by prior acid infusion: effect of decreasing intervals between infusions. AU - Siddiqui,M A, AU - Johnston,B T, AU - Leite,L P, AU - Katzka,D A, AU - Castell,D O, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 1745 EP - 8 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 91 IS - 9 N2 - OBJECTIVE: To determine the effect of decreasing time intervals between acid exposures on the sensitivity of the esophageal mucosa. METHODS: Ten healthy subjects with no history of gastroesophageal reflux disease who were symptomatic during a modified Bernstein acid infusion test were recruited for the study. Hydrochloric acid solutions of pH 3, 2, and 1 were sequentially tested. The weakest pH solution that was perceived by the patient was used for the study. The same duration of acid infusions (9 ml/min for 5 min) were made but with decreasing time intervals between each subsequent acid infusion (30-0 min). Esophageal sensation during each of the infusions, the amount of distilled water required to raise intraesophageal pH > 4, and the duration of residual heartburn after pH > 4 were recorded. RESULTS: Seven of the 10 subjects (70%) were Bernstein-positive to pH 3, two to pH 2, and only one to pH 1 solution. The median time to initial heartburn was significantly reduced only between the initial infusion and the first subsequent acid exposure 30 min later (165 vs 51.5 s, p < 0.009). Subsequent reductions in the time interval between infusions did not significantly reduce the perception threshold. The water required to clear the esophagus to pH > 4 and time required for the residual esophageal sensation to disappear were not significantly altered throughout the study. CONCLUSIONS: These data suggest that some episodes of reflux may be felt sooner and perhaps more severely despite similar levels of acid burden in the esophagus when sensitization by a prior reflux episode occurs. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/8792692/Sensitization_of_esophageal_mucosa_by_prior_acid_infusion:_effect_of_decreasing_intervals_between_infusions_ L2 - https://medlineplus.gov/gerd.html DB - PRIME DP - Unbound Medicine ER -